BRD-K93123848_RAF 265_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K93123848_RAF 265_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APOC2 apolipoprotein C-II
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
BCL6 B-cell CLL/lymphoma 6
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
C6ORF48 chromosome 6 open reading frame 48
CBS cystathionine-beta-synthase
CES1 carboxylesterase 1
COLEC12 collectin sub-family member 12
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
EFS embryonal Fyn-associated substrate
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
GCLC glutamate-cysteine ligase, catalytic subunit
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPR183 G protein-coupled receptor 183
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFRD1 interferon-related developmental regulator 1
IGFBP1 insulin-like growth factor binding protein 1
KIAA1598
LYPD1 LY6/PLAUR domain containing 1
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NBPF10 neuroblastoma breakpoint family, member 10
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PPL periplakin
PRKCA protein kinase C, alpha
PRKCI protein kinase C, iota
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTX3 pentraxin 3, long
RBKS ribokinase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
TNS3 tensin 3
TRA2A transformer 2 alpha homolog (Drosophila)
TRIOBP TRIO and F-actin binding protein
TUG1 taurine up-regulated 1 (non-protein coding)
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
AQP1 aquaporin 1 (Colton blood group)
CD59 CD59 molecule, complement regulatory protein
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CTGF connective tissue growth factor
DSG2 desmoglein 2
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GPI glucose-6-phosphate isomerase
HPRT1 hypoxanthine phosphoribosyltransferase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
ITGA6 integrin, alpha 6
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LGALS1 lectin, galactoside-binding, soluble, 1
LTF lactotransferrin
MPO myeloperoxidase
PGK1 phosphoglycerate kinase 1
RGS5 regulator of G-protein signaling 5
S100P S100 calcium binding protein P
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPTBN1 spectrin, beta, non-erythrocytic 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
VDAC1 voltage-dependent anion channel 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Funding