BRD-K93127801_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K93127801_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADGRL1 adhesion G protein-coupled receptor L1
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BEX1 brain expressed, X-linked 1
CHMP4A charged multivesicular body protein 4A
CPE carboxypeptidase E
CX3CR1 chemokine (C-X3-C motif) receptor 1
DLK1 delta-like 1 homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGFBP5 insulin-like growth factor binding protein 5
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
METTL7A methyltransferase like 7A
MT1M metallothionein 1M
NEFL neurofilament, light polypeptide
NPTX2 neuronal pentraxin II
NSDHL NAD(P) dependent steroid dehydrogenase-like
NTS neurotensin
PRR15L proline rich 15-like
PTX3 pentraxin 3, long
RAB29 RAB29, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN2 reticulon 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNX7 sorting nexin 7
SOCS2 suppressor of cytokine signaling 2
SPON1 spondin 1, extracellular matrix protein
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
TBX3 T-box 3
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
VCAN versican

decreased expression

Symbol Name
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNF cyclin F
CNPY3 canopy FGF signaling regulator 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GSTA4 glutathione S-transferase alpha 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP6 insulin-like growth factor binding protein 6
MYO1B myosin IB
RHOBTB3 Rho-related BTB domain containing 3
RPL36 ribosomal protein L36
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SATB1 SATB homeobox 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TBX2 T-box 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPM4 tropomyosin 4
WFS1 Wolfram syndrome 1 (wolframin)
YBX3 Y box binding protein 3
Funding