BRD-K93747373_HG-5-113-01_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K93747373_HG-5-113-01_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AP1M2 adaptor-related protein complex 1, mu 2 subunit
ARMCX2 armadillo repeat containing, X-linked 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHRS7 dehydrogenase/reductase (SDR family) member 7
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ESR1 estrogen receptor 1
GADD45A growth arrest and DNA-damage-inducible, alpha
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HOOK2 hook microtubule-tethering protein 2
IFI27 interferon, alpha-inducible protein 27
IGKV4-1 immunoglobulin kappa variable 4-1
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0753 KIAA0753
KRT23 keratin 23, type I
KRT8 keratin 8, type II
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
NR4A2 nuclear receptor subfamily 4, group A, member 2
OASL 2'-5'-oligoadenylate synthetase-like
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
PROM1 prominin 1
RABGGTB Rab geranylgeranyltransferase, beta subunit
RIOK3 RIO kinase 3
RSAD2 radical S-adenosyl methionine domain containing 2
RSL1D1 ribosomal L1 domain containing 1
SESN1 sestrin 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIM22 tripartite motif containing 22
UFM1 ubiquitin-fold modifier 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CORO1A coronin, actin binding protein, 1A
CTSC cathepsin C
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNM1 dynamin 1
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LMNB2 lamin B2
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MEX3D mex-3 RNA binding family member D
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAP1L1 nucleosome assembly protein 1-like 1
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NFIB nuclear factor I/B
PBK PDZ binding kinase
PKP4 plakophilin 4
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSIP1 PC4 and SFRS1 interacting protein 1
PTMA prothymosin, alpha
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPTBN1 spectrin, beta, non-erythrocytic 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYT1 synaptotagmin I
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TGM2 transglutaminase 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
UBE2C ubiquitin-conjugating enzyme E2C
ZNF185 zinc finger protein 185 (LIM domain)
ZNF22 zinc finger protein 22
Funding