BRD-K93788137_PF-431396_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K93788137_PF-431396_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMOTL2 angiomotin like 2
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CFB complement factor B
CHRDL1 chordin-like 1
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
EMP2 epithelial membrane protein 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FN1 fibronectin 1
GPX3 glutathione peroxidase 3
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KRT14 keratin 14, type I
LCN2 lipocalin 2
LIMA1 LIM domain and actin binding 1
MGLL monoglyceride lipase
PROM1 prominin 1
PYCARD PYD and CARD domain containing
RGS1 regulator of G-protein signaling 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
STK26 serine/threonine protein kinase 26
TGFA transforming growth factor, alpha
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TPD52L1 tumor protein D52-like 1
TRAF5 TNF receptor-associated factor 5
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UGDH UDP-glucose 6-dehydrogenase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANKRD10 ankyrin repeat domain 10
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BIRC5 baculoviral IAP repeat containing 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL5 chemokine (C-X-C motif) ligand 5
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO5 F-box protein 5
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MYBPC1 myosin binding protein C, slow type
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID2 nidogen 2 (osteonidogen)
NTS neurotensin
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PSRC1 proline/serine-rich coiled-coil 1
RAD51C RAD51 paralog C
RFC5 replication factor C (activator 1) 5, 36.5kDa
SHCBP1 SHC SH2-domain binding protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
VCAN versican
VDAC1 voltage-dependent anion channel 1
VRK1 vaccinia related kinase 1
Funding