BRD-K94012289_OSI-027_BT20_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K94012289_OSI-027_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
ANPEP alanyl (membrane) aminopeptidase
ARMCX1 armadillo repeat containing, X-linked 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
CAMLG calcium modulating ligand
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CST1 cystatin SN
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FOXO4 forkhead box O4
GCC2 GRIP and coiled-coil domain containing 2
GLS glutaminase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
INSR insulin receptor
JMJD1C jumonji domain containing 1C
KDM5A lysine (K)-specific demethylase 5A
KIF13B kinesin family member 13B
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LAMB2 laminin, beta 2 (laminin S)
LINC00342 long intergenic non-protein coding RNA 342
LXN latexin
MAN2B1 mannosidase, alpha, class 2B, member 1
MLPH melanophilin
MT1F metallothionein 1F
N4BP2L1 NEDD4 binding protein 2-like 1
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBSL1 obscurin-like 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RAB4A RAB4A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RAP1GAP2 RAP1 GTPase activating protein 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBP1 retinol binding protein 1, cellular
RNASE4 ribonuclease, RNase A family, 4
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC38A1 solute carrier family 38, member 1
SMAD3 SMAD family member 3
SORBS2 sorbin and SH3 domain containing 2
SOS2 son of sevenless homolog 2 (Drosophila)
SRRM2 serine/arginine repetitive matrix 2
SST somatostatin
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TRIM2 tripartite motif containing 2
TTC3 tetratricopeptide repeat domain 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
VCAN versican
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASF1B anti-silencing function 1B histone chaperone
C1QBP complement component 1, q subcomponent binding protein
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPU centromere protein U
CSE1L CSE1 chromosome segregation 1-like (yeast)
ENO1 enolase 1, (alpha)
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
HK2 hexokinase 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICMT isoprenylcysteine carboxyl methyltransferase
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MINA MYC induced nuclear antigen
MMP12 matrix metallopeptidase 12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCB protein kinase C, beta
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SNRPF small nuclear ribonucleoprotein polypeptide F
SNX10 sorting nexin 10
SRM spermidine synthase
TK1 thymidine kinase 1, soluble
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
Funding