BRD-K94012289_OSI-027_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

252 genes differentially expressed following the BRD-K94012289_OSI-027_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
ANXA4 annexin A4
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARMCX1 armadillo repeat containing, X-linked 1
ATF4 activating transcription factor 4
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BEX4 brain expressed, X-linked 4
C6ORF48 chromosome 6 open reading frame 48
C9ORF3 chromosome 9 open reading frame 3
CAMLG calcium modulating ligand
CCDC28A coiled-coil domain containing 28A
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CD9 CD9 molecule
CDC25B cell division cycle 25B
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLDN10 claudin 10
CREBL2 cAMP responsive element binding protein-like 2
CSNK2A2 casein kinase 2, alpha prime polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4A2 eukaryotic translation initiation factor 4A2
EIF4B eukaryotic translation initiation factor 4B
ESD esterase D
FAM134A family with sequence similarity 134, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FXR1 fragile X mental retardation, autosomal homolog 1
GAA glucosidase, alpha; acid
GAB2 GRB2-associated binding protein 2
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GNPDA1 glucosamine-6-phosphate deaminase 1
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HEBP1 heme binding protein 1
HINT1 histidine triad nucleotide binding protein 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JAM3 junctional adhesion molecule 3
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KLK11 kallikrein-related peptidase 11
KRT7 keratin 7, type II
LAMP2 lysosomal-associated membrane protein 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC399491
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MPPED2 metallophosphoesterase domain containing 2
MYLK myosin light chain kinase
NCOA4 nuclear receptor coactivator 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NFE2L1 nuclear factor, erythroid 2-like 1
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL1A oxysterol binding protein-like 1A
OXA1L oxidase (cytochrome c) assembly 1-like
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCBP2 poly(rC) binding protein 2
PDGFC platelet derived growth factor C
PDZK1IP1 PDZK1 interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PSAP prosaposin
QARS glutaminyl-tRNA synthetase
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RNF13 ring finger protein 13
RPL36 ribosomal protein L36
RPS14P3 ribosomal protein S14 pseudogene 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RSL1D1 ribosomal L1 domain containing 1
RSL24D1 ribosomal L24 domain containing 1
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SCAMP1 secretory carrier membrane protein 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SFTPB surfactant protein B
SKAP2 src kinase associated phosphoprotein 2
SLC16A6 solute carrier family 16, member 6
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SSBP2 single-stranded DNA binding protein 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYF2 SYF2 pre-mRNA-splicing factor
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
UBXN7 UBX domain protein 7
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
WDR45 WD repeat domain 45
YBX3 Y box binding protein 3
YPEL5 yippee-like 5 (Drosophila)
ZC2HC1A zinc finger, C2HC-type containing 1A
ZMAT3 zinc finger, matrin-type 3
ZNF277 zinc finger protein 277
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABHD6 abhydrolase domain containing 6
ACAT2 acetyl-CoA acetyltransferase 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKAP7 A kinase (PRKA) anchor protein 7
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CKB creatine kinase, brain
CNN3 calponin 3, acidic
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
FABP1 fatty acid binding protein 1, liver
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR4 fibroblast growth factor receptor 4
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
HELLS helicase, lymphoid-specific
HMBS hydroxymethylbilane synthase
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
ITM2A integral membrane protein 2A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG2 non-SMC condensin II complex, subunit G2
NLRP2 NLR family, pyrin domain containing 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
OLFM1 olfactomedin 1
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PKP2 plakophilin 2
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51 RAD51 recombinase
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SDC1 syndecan 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
STRA13 stimulated by retinoic acid 13
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VRK1 vaccinia related kinase 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZWINT ZW10 interacting kinetochore protein
Funding