BRD-K94012289_OSI-027_HS578T_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K94012289_OSI-027_HS578T_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL2 adhesion G protein-coupled receptor L2
AMIGO2 adhesion molecule with Ig-like domain 2
ARG1 arginase 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP4 bone morphogenetic protein 4
CD14 CD14 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHN1 chimerin 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPE carboxypeptidase E
CPT1A carnitine palmitoyltransferase 1A (liver)
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
DEFB1 defensin, beta 1
DENND2D DENN/MADD domain containing 2D
DKK3 dickkopf WNT signaling pathway inhibitor 3
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FNBP1 formin binding protein 1
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPX2 glutathione peroxidase 2
IGL immunoglobulin lambda locus
ITGAV integrin, alpha V
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KIZ kizuna centrosomal protein
KRT23 keratin 23, type I
LAMC2 laminin, gamma 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL10 oxysterol binding protein-like 10
PDGFC platelet derived growth factor C
PRDX2 peroxiredoxin 2
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB4A RAB4A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SULF1 sulfatase 1
SYT1 synaptotagmin I
TNS3 tensin 3
UQCRB ubiquinol-cytochrome c reductase binding protein
VCAN versican

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMP3 epithelial membrane protein 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HELLS helicase, lymphoid-specific
HK2 hexokinase 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIF20A kinesin family member 20A
LMNB1 lamin B1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
OPN3 opsin 3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSPH phosphoserine phosphatase
RRM1 ribonucleotide reductase M1
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPATS2L spermatogenesis associated, serine-rich 2-like
SRGN serglycin
TIMELESS timeless circadian clock
TYMS thymidylate synthetase
VEGFA vascular endothelial growth factor A
Funding