BRD-K94012289_OSI-027_LNCAP_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K94012289_OSI-027_LNCAP_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOC1 apolipoprotein C-I
AQP3 aquaporin 3 (Gill blood group)
ASRGL1 asparaginase like 1
CAST calpastatin
CD99 CD99 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CLEC11A C-type lectin domain family 11, member A
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSZ cathepsin Z
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA3 EPH receptor A3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGG fibrinogen gamma chain
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
KRT18 keratin 18, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPAR2 lysophosphatidic acid receptor 2
MAP2K5 mitogen-activated protein kinase kinase 5
MUC1 mucin 1, cell surface associated
NBL1 neuroblastoma 1, DAN family BMP antagonist
NPY neuropeptide Y
PEG3 paternally expressed 3
PRF1 perforin 1 (pore forming protein)
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PTGIS prostaglandin I2 (prostacyclin) synthase
RRBP1 ribosome binding protein 1
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPA2 surfactant protein A2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPDEF SAM pointed domain containing ETS transcription factor
TARP TCR gamma alternate reading frame protein
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TRAC T cell receptor alpha constant
TRBC1 T cell receptor beta constant 1

decreased expression

Symbol Name
APOD apolipoprotein D
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
C6ORF62 chromosome 6 open reading frame 62
CCNG2 cyclin G2
CREB1 cAMP responsive element binding protein 1
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
FABP4 fatty acid binding protein 4, adipocyte
G0S2 G0/G1 switch 2
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
ING2 inhibitor of growth family, member 2
JMJD6 jumonji domain containing 6
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
LOX lysyl oxidase
LPL lipoprotein lipase
MME membrane metallo-endopeptidase
OXTR oxytocin receptor
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEG10 paternally expressed 10
PLAT plasminogen activator, tissue
RND3 Rho family GTPase 3
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
Funding