BRD-K94012289_OSI-027_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K94012289_OSI-027_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ANXA4 annexin A4
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CCNG1 cyclin G1
CCNG2 cyclin G2
CD24 CD24 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CRYAB crystallin, alpha B
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF4B eukaryotic translation initiation factor 4B
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM63A family with sequence similarity 63, member A
FAS Fas cell surface death receptor
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD2 FXYD domain containing ion transport regulator 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HNMT histamine N-methyltransferase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KLHL21 kelch-like family member 21
LDOC1 leucine zipper, down-regulated in cancer 1
LETMD1 LETM1 domain containing 1
LXN latexin
MAL mal, T-cell differentiation protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
PCBP2 poly(rC) binding protein 2
PDLIM1 PDZ and LIM domain 1
PILRB paired immunoglobin-like type 2 receptor beta
PLAU plasminogen activator, urokinase
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTEN phosphatase and tensin homolog
PTX3 pentraxin 3, long
RAB13 RAB13, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNMT RNA (guanine-7-) methyltransferase
RPL31 ribosomal protein L31
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC35E2B solute carrier family 35, member E2B
SPATA20 spermatogenesis associated 20
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TSPAN1 tetraspanin 1
TSPAN31 tetraspanin 31
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
USP34 ubiquitin specific peptidase 34
VCAN versican
WASL Wiskott-Aldrich syndrome-like
WDR45 WD repeat domain 45
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADI1 acireductone dioxygenase 1
AK1 adenylate kinase 1
ARPC5L actin related protein 2/3 complex, subunit 5-like
BRCA1 breast cancer 1, early onset
C20ORF24 chromosome 20 open reading frame 24
C4BPA complement component 4 binding protein, alpha
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
EREG epiregulin
FEN1 flap structure-specific endonuclease 1
FOXF1 forkhead box F1
GAL galanin/GMAP prepropeptide
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HAT1 histone acetyltransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
LAPTM4B lysosomal protein transmembrane 4 beta
MAP2K3 mitogen-activated protein kinase kinase 3
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
ODC1 ornithine decarboxylase 1
PARP2 poly (ADP-ribose) polymerase 2
PGC progastricsin (pepsinogen C)
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RAD51 RAD51 recombinase
RAD54B RAD54 homolog B (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPTSSA serine palmitoyltransferase, small subunit A
TFRC transferrin receptor
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TMPO thymopoietin
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
Funding