BRD-K94012289_OSI-027_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

275 genes differentially expressed following the BRD-K94012289_OSI-027_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA4 annexin A4
ARMCX6 armadillo repeat containing, X-linked 6
ASMTL acetylserotonin O-methyltransferase-like
BASP1 brain abundant, membrane attached signal protein 1
BCAS1 breast carcinoma amplified sequence 1
BDKRB2 bradykinin receptor B2
C2CD2 C2 calcium-dependent domain containing 2
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CAPN3 calpain 3, (p94)
CAV1 caveolin 1, caveolae protein, 22kDa
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCNG1 cyclin G1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC16 cell division cycle 16
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDK7 cyclin-dependent kinase 7
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFLAR CASP8 and FADD-like apoptosis regulator
CIRBP cold inducible RNA binding protein
CLU clusterin
CTSL cathepsin L
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DARS aspartyl-tRNA synthetase
DCLK1 doublecortin-like kinase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DSG2 desmoglein 2
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
EXOC1 exocyst complex component 1
FLNB filamin B, beta
FOXO3 forkhead box O3
FST follistatin
FXR1 fragile X mental retardation, autosomal homolog 1
GALC galactosylceramidase
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GM2A GM2 ganglioside activator
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HLA-E major histocompatibility complex, class I, E
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IL18 interleukin 18
IL20RA interleukin 20 receptor, alpha
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLHDC2 kelch domain containing 2
KRT18 keratin 18, type I
LAMP2 lysosomal-associated membrane protein 2
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR1 lysophosphatidic acid receptor 1
LXN latexin
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MAN2A1 mannosidase, alpha, class 2A, member 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MGLL monoglyceride lipase
MLPH melanophilin
MOAP1 modulator of apoptosis 1
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
MYOF myoferlin
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NCK2 NCK adaptor protein 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMI N-myc (and STAT) interactor
NPIPB3 nuclear pore complex interacting protein family, member B3
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRIP1 nuclear receptor interacting protein 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PARP4 poly (ADP-ribose) polymerase family, member 4
PCM1 pericentriolar material 1
PDLIM5 PDZ and LIM domain 5
PF4 platelet factor 4
PHF11 PHD finger protein 11
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPL periplakin
PTX3 pentraxin 3, long
QARS glutaminyl-tRNA synthetase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
REEP5 receptor accessory protein 5
RGS10 regulator of G-protein signaling 10
RND3 Rho family GTPase 3
RPL36 ribosomal protein L36
RSL1D1 ribosomal L1 domain containing 1
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SH3BP4 SH3-domain binding protein 4
SH3YL1 SH3 and SYLF domain containing 1
SMAD3 SMAD family member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNAP25 synaptosomal-associated protein, 25kDa
SNX2 sorting nexin 2
SP110 SP110 nuclear body protein
SPDEF SAM pointed domain containing ETS transcription factor
SQSTM1 sequestosome 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNJ2 synaptojanin 2
SYT1 synaptotagmin I
TANK TRAF family member-associated NFKB activator
TFF3 trefoil factor 3 (intestinal)
TNS3 tensin 3
TRAF5 TNF receptor-associated factor 5
TRIM2 tripartite motif containing 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
USP34 ubiquitin specific peptidase 34
WASL Wiskott-Aldrich syndrome-like
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
AMD1 adenosylmethionine decarboxylase 1
AQP1 aquaporin 1 (Colton blood group)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BANF1 barrier to autointegration factor 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIRC5 baculoviral IAP repeat containing 5
C1QBP complement component 1, q subcomponent binding protein
C20ORF24 chromosome 20 open reading frame 24
CA2 carbonic anhydrase II
CCR2 chemokine (C-C motif) receptor 2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CRYAB crystallin, alpha B
CTPS1 CTP synthase 1
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DEGS1 delta(4)-desaturase, sphingolipid 1
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELP5 elongator acetyltransferase complex subunit 5
ENO1 enolase 1, (alpha)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FKBP1A FK506 binding protein 1A, 12kDa
FOXG1 forkhead box G1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GOLT1B golgi transport 1B
GSTA1 glutathione S-transferase alpha 1
H2AFX H2A histone family, member X
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HRASLS HRAS-like suppressor
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPE1 heat shock 10kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IRF8 interferon regulatory factor 8
KANK1 KN motif and ankyrin repeat domains 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAGE3 L antigen family, member 3
LBR lamin B receptor
LPL lipoprotein lipase
LRRC59 leucine rich repeat containing 59
MALT1 MALT1 paracaspase
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MED21 mediator complex subunit 21
MLEC malectin
MOXD1 monooxygenase, DBH-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NME1 NME/NM23 nucleoside diphosphate kinase 1
PARP2 poly (ADP-ribose) polymerase 2
PCCB propionyl CoA carboxylase, beta polypeptide
PDZK1 PDZ domain containing 1
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PGAM1 phosphoglycerate mutase 1 (brain)
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SDF2L1 stromal cell-derived factor 2-like 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35B1 solute carrier family 35, member B1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORBS1 sorbin and SH3 domain containing 1
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STK26 serine/threonine protein kinase 26
STMN1 stathmin 1
TCL1A T-cell leukemia/lymphoma 1A
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TNC tenascin C
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPM1 tropomyosin 1 (alpha)
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VBP1 von Hippel-Lindau binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZWINT ZW10 interacting kinetochore protein
Funding