| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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266 genes differentially expressed following the BRD-K94012289_OSI-027_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
| ADIRF | adipogenesis regulatory factor |
| ADPRM | ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent |
| ADRB2 | adrenoceptor beta 2, surface |
| AHNAK | AHNAK nucleoprotein |
| ALCAM | activated leukocyte cell adhesion molecule |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 |
| ANKRA2 | ankyrin repeat, family A (RFXANK-like), 2 |
| ARMCX6 | armadillo repeat containing, X-linked 6 |
| ATP5G2 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| C6ORF48 | chromosome 6 open reading frame 48 |
| CAMLG | calcium modulating ligand |
| CCNG2 | cyclin G2 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) |
| CDK7 | cyclin-dependent kinase 7 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| CIRBP | cold inducible RNA binding protein |
| CLDN4 | claudin 4 |
| CST1 | cystatin SN |
| CTSL | cathepsin L |
| CYTH1 | cytohesin 1 |
| DARS | aspartyl-tRNA synthetase |
| DCLK1 | doublecortin-like kinase 1 |
| DLK1 | delta-like 1 homolog (Drosophila) |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 |
| DSG2 | desmoglein 2 |
| DUSP4 | dual specificity phosphatase 4 |
| DUSP5 | dual specificity phosphatase 5 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa |
| EIF3D | eukaryotic translation initiation factor 3, subunit D |
| EIF3E | eukaryotic translation initiation factor 3, subunit E |
| EIF4B | eukaryotic translation initiation factor 4B |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
| ESR1 | estrogen receptor 1 |
| FNBP1 | formin binding protein 1 |
| FOXO3 | forkhead box O3 |
| FST | follistatin |
| FXR1 | fragile X mental retardation, autosomal homolog 1 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 |
| GCC2 | GRIP and coiled-coil domain containing 2 |
| GDF15 | growth differentiation factor 15 |
| GLRX | glutaredoxin (thioltransferase) |
| GLTSCR2 | glioma tumor suppressor candidate region gene 2 |
| GMPR | guanosine monophosphate reductase |
| GOLGA8A | golgin A8 family, member A |
| GRB7 | growth factor receptor-bound protein 7 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 |
| HBP1 | HMG-box transcription factor 1 |
| HES1 | hes family bHLH transcription factor 1 |
| HNMT | histamine N-methyltransferase |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 |
| IFI27 | interferon, alpha-inducible protein 27 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
| IRS1 | insulin receptor substrate 1 |
| IRS2 | insulin receptor substrate 2 |
| ITGB5 | integrin, beta 5 |
| JMJD1C | jumonji domain containing 1C |
| KIAA0355 | KIAA0355 |
| KLHDC2 | kelch domain containing 2 |
| LAMP2 | lysosomal-associated membrane protein 2 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 |
| LGALS8 | lectin, galactoside-binding, soluble, 8 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) |
| LXN | latexin |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 |
| MBNL2 | muscleblind-like splicing regulator 2 |
| MITF | microphthalmia-associated transcription factor |
| MLPH | melanophilin |
| MOAP1 | modulator of apoptosis 1 |
| MTSS1 | metastasis suppressor 1 |
| MTUS1 | microtubule associated tumor suppressor 1 |
| MVP | major vault protein |
| MXI1 | MAX interactor 1, dimerization protein |
| MYO6 | myosin VI |
| N4BP2L1 | NEDD4 binding protein 2-like 1 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 |
| NBR1 | neighbor of BRCA1 gene 1 |
| NCK2 | NCK adaptor protein 2 |
| NDRG1 | N-myc downstream regulated 1 |
| NMI | N-myc (and STAT) interactor |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 |
| NRIP1 | nuclear receptor interacting protein 1 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PDP1 | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
| PEG3 | paternally expressed 3 |
| PLA2G16 | phospholipase A2, group XVI |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa |
| PRAME | preferentially expressed antigen in melanoma |
| PSD3 | pleckstrin and Sec7 domain containing 3 |
| QARS | glutaminyl-tRNA synthetase |
| RAP1GAP | RAP1 GTPase activating protein |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 |
| REEP5 | receptor accessory protein 5 |
| RGS10 | regulator of G-protein signaling 10 |
| RIOK3 | RIO kinase 3 |
| RPL36 | ribosomal protein L36 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 |
| RSL1D1 | ribosomal L1 domain containing 1 |
| RSL24D1 | ribosomal L24 domain containing 1 |
| SCGB2A1 | secretoglobin, family 2A, member 1 |
| SFRP4 | secreted frizzled-related protein 4 |
| SH3YL1 | SH3 and SYLF domain containing 1 |
| SLC22A18 | solute carrier family 22, member 18 |
| SMAD3 | SMAD family member 3 |
| SNX2 | sorting nexin 2 |
| SOX4 | SRY (sex determining region Y)-box 4 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 |
| SYF2 | SYF2 pre-mRNA-splicing factor |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| TFPI2 | tissue factor pathway inhibitor 2 |
| TMC5 | transmembrane channel-like 5 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) |
| TTC17 | tetratricopeptide repeat domain 17 |
| TXNIP | thioredoxin interacting protein |
| WASL | Wiskott-Aldrich syndrome-like |
| WDR45 | WD repeat domain 45 |
| XIST | X inactive specific transcript (non-protein coding) |
| ZBED5 | zinc finger, BED-type containing 5 |
| ZNF217 | zinc finger protein 217 |
| ZNF277 | zinc finger protein 277 |
| Symbol | Name |
|---|---|
| ABAT | 4-aminobutyrate aminotransferase |
| AK1 | adenylate kinase 1 |
| ALOX5 | arachidonate 5-lipoxygenase |
| ARPC5L | actin related protein 2/3 complex, subunit 5-like |
| ATAD2 | ATPase family, AAA domain containing 2 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 |
| AURKA | aurora kinase A |
| AURKB | aurora kinase B |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BMP2 | bone morphogenetic protein 2 |
| C20ORF24 | chromosome 20 open reading frame 24 |
| CALB2 | calbindin 2 |
| CALR | calreticulin |
| CCNA2 | cyclin A2 |
| CDC25A | cell division cycle 25A |
| CDCA3 | cell division cycle associated 3 |
| CDK1 | cyclin-dependent kinase 1 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
| CDKN3 | cyclin-dependent kinase inhibitor 3 |
| CENPA | centromere protein A |
| CENPU | centromere protein U |
| CKAP4 | cytoskeleton-associated protein 4 |
| CKLF | chemokine-like factor |
| CKS1B | CDC28 protein kinase regulatory subunit 1B |
| CKS2 | CDC28 protein kinase regulatory subunit 2 |
| COL1A2 | collagen, type I, alpha 2 |
| COTL1 | coactosin-like F-actin binding protein 1 |
| CRELD2 | cysteine-rich with EGF-like domains 2 |
| CTPS1 | CTP synthase 1 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| CXCL13 | chemokine (C-X-C motif) ligand 13 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 |
| DCK | deoxycytidine kinase |
| DCXR | dicarbonyl/L-xylulose reductase |
| DHCR24 | 24-dehydrocholesterol reductase |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| FEN1 | flap structure-specific endonuclease 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FKBP1A | FK506 binding protein 1A, 12kDa |
| FKBP5 | FK506 binding protein 5 |
| FRZB | frizzled-related protein |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GOLT1B | golgi transport 1B |
| GPM6B | glycoprotein M6B |
| H2AFX | H2A histone family, member X |
| H2AFZ | H2A histone family, member Z |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 |
| HIGD1A | HIG1 hypoxia inducible domain family, member 1A |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) |
| HN1 | hematological and neurological expressed 1 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B |
| HSPA1A | heat shock 70kDa protein 1A |
| ICMT | isoprenylcysteine carboxyl methyltransferase |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 |
| IFRD2 | interferon-related developmental regulator 2 |
| IGHM | immunoglobulin heavy constant mu |
| IGKC | immunoglobulin kappa constant |
| IGKV1-5 | immunoglobulin kappa variable 1-5 |
| IGL | immunoglobulin lambda locus |
| IL1R2 | interleukin 1 receptor, type II |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
| JCHAIN | joining chain of multimeric IgA and IgM |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
| KRT6B | keratin 6B, type II |
| LBR | lamin B receptor |
| LMO3 | LIM domain only 3 (rhombotin-like 2) |
| LMO4 | LIM domain only 4 |
| LRRC59 | leucine rich repeat containing 59 |
| LYZ | lysozyme |
| MALT1 | MALT1 paracaspase |
| MARS | methionyl-tRNA synthetase |
| MCM10 | minichromosome maintenance complex component 10 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| MYCBP | MYC binding protein |
| NCAM1 | neural cell adhesion molecule 1 |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 |
| NOP56 | NOP56 ribonucleoprotein |
| NSFL1C | NSFL1 (p97) cofactor (p47) |
| NXT1 | nuclear transport factor 2-like export factor 1 |
| PARP2 | poly (ADP-ribose) polymerase 2 |
| PBK | PDZ binding kinase |
| PCNA | proliferating cell nuclear antigen |
| PHGDH | phosphoglycerate dehydrogenase |
| PI3 | peptidase inhibitor 3, skin-derived |
| PLK1 | polo-like kinase 1 |
| POSTN | periostin, osteoblast specific factor |
| POU2AF1 | POU class 2 associating factor 1 |
| PRKCB | protein kinase C, beta |
| PRPS1 | phosphoribosyl pyrophosphate synthetase 1 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) |
| RACGAP1 | Rac GTPase activating protein 1 |
| RDH11 | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) |
| RFX5 | regulatory factor X, 5 (influences HLA class II expression) |
| RRM2 | ribonucleotide reductase M2 |
| S100A2 | S100 calcium binding protein A2 |
| S100A9 | S100 calcium binding protein A9 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) |
| SDF2L1 | stromal cell-derived factor 2-like 1 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 |
| SLPI | secretory leukocyte peptidase inhibitor |
| SMCO4 | single-pass membrane protein with coiled-coil domains 4 |
| SNRPA1 | small nuclear ribonucleoprotein polypeptide A' |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) |
| SPRR1A | small proline-rich protein 1A |
| SRM | spermidine synthase |
| STMN1 | stathmin 1 |
| TCL1A | T-cell leukemia/lymphoma 1A |
| TFRC | transferrin receptor |
| TMEM45A | transmembrane protein 45A |
| TMEM47 | transmembrane protein 47 |
| TMPO | thymopoietin |
| TPSAB1 | tryptase alpha/beta 1 |
| TPX2 | TPX2, microtubule-associated |
| TRA2B | transformer 2 beta homolog (Drosophila) |
| TRAPPC3 | trafficking protein particle complex 3 |
| TSPAN13 | tetraspanin 13 |
| TUBA4A | tubulin, alpha 4a |
| TUBB4B | tubulin, beta 4B class IVb |
| TUBG1 | tubulin, gamma 1 |
| TYMS | thymidylate synthetase |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| ZWINT | ZW10 interacting kinetochore protein |
