BRD-K94012289_OSI-027_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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72 genes differentially expressed following the BRD-K94012289_OSI-027_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARID5B AT rich interactive domain 5B (MRF1-like)
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN4 claudin 4
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
GDF15 growth differentiation factor 15
GLS glutaminase
GRB7 growth factor receptor-bound protein 7
HMGB2 high mobility group box 2
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
KIAA0355 KIAA0355
LGALS1 lectin, galactoside-binding, soluble, 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PROS1 protein S (alpha)
RGS1 regulator of G-protein signaling 1
RSAD2 radical S-adenosyl methionine domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SPP1 secreted phosphoprotein 1
TES testin LIM domain protein
THBS1 thrombospondin 1
VCAN versican

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
C3 complement component 3
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
COL4A6 collagen, type IV, alpha 6
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
DES desmin
FBLN1 fibulin 1
FOXF1 forkhead box F1
FOXF2 forkhead box F2
FRZB frizzled-related protein
HOXB2 homeobox B2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1R2 interleukin 1 receptor, type II
ITM2A integral membrane protein 2A
LHFP lipoma HMGIC fusion partner
LRRC17 leucine rich repeat containing 17
MATN2 matrilin 2
MFAP4 microfibrillar-associated protein 4
NES nestin
ORM1 orosomucoid 1
PCDH9 protocadherin 9
PFN2 profilin 2
PGC progastricsin (pepsinogen C)
PI3 peptidase inhibitor 3, skin-derived
RGS5 regulator of G-protein signaling 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMTN smoothelin
SPINK1 serine peptidase inhibitor, Kazal type 1
TFF1 trefoil factor 1
TLR4 toll-like receptor 4
TMEM176B transmembrane protein 176B
TSPAN8 tetraspanin 8