BRD-K94176593_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K94176593_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTN1 actinin, alpha 1
AK4 adenylate kinase 4
ASPN asporin
CLIC4 chloride intracellular channel 4
CNOT4 CCR4-NOT transcription complex, subunit 4
DDIT4 DNA-damage-inducible transcript 4
EGR1 early growth response 1
EMP3 epithelial membrane protein 3
FUCA1 fucosidase, alpha-L- 1, tissue
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INPP1 inositol polyphosphate-1-phosphatase
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LTF lactotransferrin
MAP7 microtubule-associated protein 7
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PODXL podocalyxin-like
PSAT1 phosphoserine aminotransferase 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SEC62 SEC62 homolog (S. cerevisiae)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STAT1 signal transducer and activator of transcription 1, 91kDa
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPD52L1 tumor protein D52-like 1
TRAC T cell receptor alpha constant

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
C2CD5 C2 calcium-dependent domain containing 5
C3ORF14 chromosome 3 open reading frame 14
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EMP2 epithelial membrane protein 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FBXO21 F-box protein 21
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
HN1 hematological and neurological expressed 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
KCNK3 potassium channel, two pore domain subfamily K, member 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
NEFH neurofilament, heavy polypeptide
NPTX2 neuronal pentraxin II
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
OLFM4 olfactomedin 4
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGK1 phosphoglycerate kinase 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLBD1 phospholipase B domain containing 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG3A regenerating islet-derived 3 alpha
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFN stratifin
SMYD2 SET and MYND domain containing 2
SPARCL1 SPARC-like 1 (hevin)
TCF4 transcription factor 4
TFRC transferrin receptor
TMEM100 transmembrane protein 100
TMSB15A thymosin beta 15a
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF586 zinc finger protein 586
ZW10 zw10 kinetochore protein
Funding