BRD-K94176593_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K94176593_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BCL6 B-cell CLL/lymphoma 6
C3 complement component 3
DOK5 docking protein 5
FADS3 fatty acid desaturase 3
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
POSTN periostin, osteoblast specific factor
RBP4 retinol binding protein 4, plasma
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SDC3 syndecan 3
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
THBS1 thrombospondin 1
TNS1 tensin 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADGRG2 adhesion G protein-coupled receptor G2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATF3 activating transcription factor 3
C9ORF16 chromosome 9 open reading frame 16
CD69 CD69 molecule
CTBP1 C-terminal binding protein 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DMD dystrophin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FLRT2 fibronectin leucine rich transmembrane protein 2
H2AFX H2A histone family, member X
HOPX HOP homeobox
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUN jun proto-oncogene
KYNU kynureninase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKSL1 MARCKS-like 1
MEGF9 multiple EGF-like-domains 9
MRPS2 mitochondrial ribosomal protein S2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFL neurofilament, light polypeptide
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCH protein kinase C, eta
PROM1 prominin 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
RAB14 RAB14, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
SET SET nuclear proto-oncogene
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
STMN1 stathmin 1
TBC1D4 TBC1 domain family, member 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TUBB4B tubulin, beta 4B class IVb
Funding