BRD-K94176593_TWS-119_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K94176593_TWS-119_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
CD164 CD164 molecule, sialomucin
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CRABP2 cellular retinoic acid binding protein 2
CTSH cathepsin H
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FAM129A family with sequence similarity 129, member A
HSPA1A heat shock 70kDa protein 1A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LGALS1 lectin, galactoside-binding, soluble, 1
LYN LYN proto-oncogene, Src family tyrosine kinase
PLAC8 placenta-specific 8
RAB31 RAB31, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
SCYL3 SCY1-like 3 (S. cerevisiae)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYNGR2 synaptogyrin 2
TYROBP TYRO protein tyrosine kinase binding protein
VLDLR very low density lipoprotein receptor
WFDC2 WAP four-disulfide core domain 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
APOB apolipoprotein B
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CREB1 cAMP responsive element binding protein 1
EGR3 early growth response 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F13A1 coagulation factor XIII, A1 polypeptide
FN1 fibronectin 1
GBP2 guanylate binding protein 2, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HNMT histamine N-methyltransferase
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LAMB1 laminin, beta 1
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MTSS1 metastasis suppressor 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NID1 nidogen 1
NT5E 5'-nucleotidase, ecto (CD73)
RAP1GAP RAP1 GTPase activating protein
SCRG1 stimulator of chondrogenesis 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SOX9 SRY (sex determining region Y)-box 9
TBX3 T-box 3
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TPM1 tropomyosin 1 (alpha)
WBP5 WW domain binding protein 5
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
Funding