BRD-K94325918_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

43 genes differentially expressed following the BRD-K94325918_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
IER3 immediate early response 3
ISG20 interferon stimulated exonuclease gene 20kDa
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
NFIL3 nuclear factor, interleukin 3 regulated
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
S100P S100 calcium binding protein P
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA4 annexin A4
CD24 CD24 molecule
HSPA1A heat shock 70kDa protein 1A
MAGED1 melanoma antigen family D1
NELL2 NEL-like 2 (chicken)
SOX2 SRY (sex determining region Y)-box 2
TUBA1A tubulin, alpha 1a
Funding