BRD-K94325918_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K94325918_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
AIM2 absent in melanoma 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
ELL2 elongation factor, RNA polymerase II, 2
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FASTKD5 FAST kinase domains 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
IER2 immediate early response 2
IL4R interleukin 4 receptor
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUNB jun B proto-oncogene
KIAA1551 KIAA1551
KIF5C kinesin family member 5C
KRT14 keratin 14, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NKX3-1 NK3 homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
OSMR oncostatin M receptor
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PMEPA1 prostate transmembrane protein, androgen induced 1
PTHLH parathyroid hormone-like hormone
RBM12 RNA binding motif protein 12
RIT1 Ras-like without CAAX 1
S100A11 S100 calcium binding protein A11
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
STK17A serine/threonine kinase 17a
TACSTD2 tumor-associated calcium signal transducer 2
TBPL1 TBP-like 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBD thrombomodulin
TM4SF1 transmembrane 4 L six family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
VNN1 vanin 1
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36 ZFP36 ring finger protein
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCY adenosylhomocysteinase
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANXA4 annexin A4
BEX1 brain expressed, X-linked 1
BSG basigin (Ok blood group)
CDC20 cell division cycle 20
CNN3 calponin 3, acidic
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EFHD1 EF-hand domain family, member D1
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GOLGA8H golgin A8 family, member H
LAPTM4B lysosomal protein transmembrane 4 beta
MAN1A1 mannosidase, alpha, class 1A, member 1
MFAP5 microfibrillar associated protein 5
MMP11 matrix metallopeptidase 11
PEG10 paternally expressed 10
PHYH phytanoyl-CoA 2-hydroxylase
PNMA2 paraneoplastic Ma antigen 2
RHOBTB3 Rho-related BTB domain containing 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SOX11 SRY (sex determining region Y)-box 11
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCTA T-cell leukemia translocation altered
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM176B transmembrane protein 176B
TSPYL5 TSPY-like 5
VCAM1 vascular cell adhesion molecule 1
Funding