BRD-K95138506_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-K95138506_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CCNE2 cyclin E2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CNPY3 canopy FGF signaling regulator 3
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
DUOX2 dual oxidase 2
EGR1 early growth response 1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOSL1 FOS-like antigen 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
INSIG2 insulin induced gene 2
KDM3A lysine (K)-specific demethylase 3A
KDM7A lysine (K)-specific demethylase 7A
KIAA0355 KIAA0355
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MLF1 myeloid leukemia factor 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK1 proprotein convertase subtilisin/kexin type 1
PFKP phosphofructokinase, platelet
PLCB4 phospholipase C, beta 4
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMP22 peripheral myelin protein 22
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR7 proline rich 7 (synaptic)
PSD3 pleckstrin and Sec7 domain containing 3
PSPH phosphoserine phosphatase
PTRF polymerase I and transcript release factor
RNMT RNA (guanine-7-) methyltransferase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKAP2 src kinase associated phosphoprotein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRD T cell receptor delta locus
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
YBX3 Y box binding protein 3
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADGRA2 adhesion G protein-coupled receptor A2
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
AMIGO2 adhesion molecule with Ig-like domain 2
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CALB1 calbindin 1, 28kDa
CCNF cyclin F
CD24 CD24 molecule
CDC20 cell division cycle 20
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN3 cyclin-dependent kinase inhibitor 3
CHMP4A charged multivesicular body protein 4A
CLDN10 claudin 10
DACH1 dachshund family transcription factor 1
DEPTOR DEP domain containing MTOR-interacting protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
EFNB2 ephrin-B2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GJA1 gap junction protein, alpha 1, 43kDa
HSPA8 heat shock 70kDa protein 8
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
KIF20A kinesin family member 20A
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
MDK midkine (neurite growth-promoting factor 2)
MID1 midline 1
MXRA5 matrix-remodelling associated 5
NELL2 NEL-like 2 (chicken)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PLK1 polo-like kinase 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
VRK1 vaccinia related kinase 1
ZNF586 zinc finger protein 586
Funding