BRD-K95138506_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K95138506_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACKR3 atypical chemokine receptor 3
AK4 adenylate kinase 4
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ATF3 activating transcription factor 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
CCNE2 cyclin E2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CKB creatine kinase, brain
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM162A family with sequence similarity 162, member A
FBN1 fibrillin 1
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLC glutamate-cysteine ligase, catalytic subunit
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPI glucose-6-phosphate isomerase
GSTM3 glutathione S-transferase mu 3 (brain)
HEG1 heart development protein with EGF-like domains 1
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL6 interleukin 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JAM2 junctional adhesion molecule 2
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KIAA0355 KIAA0355
KLF4 Kruppel-like factor 4 (gut)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS8 lectin, galactoside-binding, soluble, 8
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOX lysyl oxidase
LPAR2 lysophosphatidic acid receptor 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNMA2 paraneoplastic Ma antigen 2
PPAP2B phosphatidic acid phosphatase type 2B
PRNP prion protein
RBPMS RNA binding protein with multiple splicing
RNMT RNA (guanine-7-) methyltransferase
S100A9 S100 calcium binding protein A9
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPAG4 sperm associated antigen 4
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
TFF3 trefoil factor 3 (intestinal)
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AURKA aurora kinase A
C6ORF62 chromosome 6 open reading frame 62
CCDC86 coiled-coil domain containing 86
CCNF cyclin F
CDC20 cell division cycle 20
CENPA centromere protein A
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FAR2 fatty acyl CoA reductase 2
FLRT3 fibronectin leucine rich transmembrane protein 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LGALS3 lectin, galactoside-binding, soluble, 3
LYPD3 LY6/PLAUR domain containing 3
NCALD neurocalcin delta
NFIB nuclear factor I/B
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY1R neuropeptide Y receptor Y1
NTS neurotensin
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PRPF4 pre-mRNA processing factor 4
PSRC1 proline/serine-rich coiled-coil 1
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN2 reticulon 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SPRR1A small proline-rich protein 1A
TACSTD2 tumor-associated calcium signal transducer 2
TM4SF1 transmembrane 4 L six family member 1
TRPS1 trichorhinophalangeal syndrome I
VTCN1 V-set domain containing T cell activation inhibitor 1
Funding