BRD-K95435023_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-K95435023_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ALB albumin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP2 cellular retinoic acid binding protein 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSE cathepsin E
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EGFL6 EGF-like-domain, multiple 6
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM69A family with sequence similarity 69, member A
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FXYD6 FXYD domain containing ion transport regulator 6
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GRK5 G protein-coupled receptor kinase 5
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LAMB3 laminin, beta 3
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
NAV2 neuron navigator 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PID1 phosphotyrosine interaction domain containing 1
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
PTX3 pentraxin 3, long
RABGAP1L RAB GTPase activating protein 1-like
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RIPK2 receptor-interacting serine-threonine kinase 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
TMEM30B transmembrane protein 30B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TP53BP2 tumor protein p53 binding protein 2
TRIB1 tribbles pseudokinase 1
TRPS1 trichorhinophalangeal syndrome I
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AXL AXL receptor tyrosine kinase
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK6 cyclin-dependent kinase 6
COL4A2 collagen, type IV, alpha 2
CST3 cystatin C
CTSH cathepsin H
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECI2 enoyl-CoA delta isomerase 2
EDNRB endothelin receptor type B
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FSTL1 follistatin-like 1
FXYD2 FXYD domain containing ion transport regulator 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
ICMT isoprenylcysteine carboxyl methyltransferase
IFITM2 interferon induced transmembrane protein 2
IGFBP7 insulin-like growth factor binding protein 7
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LDHB lactate dehydrogenase B
LIG1 ligase I, DNA, ATP-dependent
MGST2 microsomal glutathione S-transferase 2
MLEC malectin
MXRA7 matrix-remodelling associated 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
PLA1A phospholipase A1 member A
PLK1 polo-like kinase 1
PRKCA protein kinase C, alpha
PRSS23 protease, serine, 23
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF6 serine/arginine-rich splicing factor 6
TARBP1 TAR (HIV-1) RNA binding protein 1
TMEM106B transmembrane protein 106B
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
WDR61 WD repeat domain 61
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta