BRD-K95435023_PHA-665752_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K95435023_PHA-665752_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACVR2A activin A receptor, type IIA
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANPEP alanyl (membrane) aminopeptidase
BHLHE41 basic helix-loop-helix family, member e41
CCR2 chemokine (C-C motif) receptor 2
CD1B CD1b molecule
CD1E CD1e molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL2 dihydropyrimidinase-like 2
EGR2 early growth response 2
EGR3 early growth response 3
EPN2 epsin 2
ETV5 ets variant 5
FBXL12 F-box and leucine-rich repeat protein 12
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
IPO13 importin 13
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NPTX2 neuronal pentraxin II
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP85 nucleoporin 85kDa
PADI2 peptidyl arginine deiminase, type II
PEX11A peroxisomal biogenesis factor 11 alpha
PPAP2B phosphatidic acid phosphatase type 2B
PRSS2 protease, serine, 2 (trypsin 2)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SATB2 SATB homeobox 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPAG4 sperm associated antigen 4
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
USP1 ubiquitin specific peptidase 1
VIM vimentin
ZWINT ZW10 interacting kinetochore protein

decreased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADRB2 adrenoceptor beta 2, surface
BCL2A1 BCL2-related protein A1
BEX1 brain expressed, X-linked 1
C3AR1 complement component 3a receptor 1
CCNG2 cyclin G2
CD24 CD24 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CNN3 calponin 3, acidic
COL6A1 collagen, type VI, alpha 1
DAAM1 dishevelled associated activator of morphogenesis 1
DUSP1 dual specificity phosphatase 1
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
HOXB6 homeobox B6
IFI44L interferon-induced protein 44-like
JAG1 jagged 1
KIAA1033 KIAA1033
LAMB1 laminin, beta 1
LRRC17 leucine rich repeat containing 17
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP7 matrix metallopeptidase 7
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSX1 msh homeobox 1
MTUS1 microtubule associated tumor suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NPEPL1 aminopeptidase-like 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PEG3 paternally expressed 3
PLS3 plastin 3
RHOB ras homolog family member B
RPS11 ribosomal protein S11
SCGB2A1 secretoglobin, family 2A, member 1
SDPR serum deprivation response
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNAP25 synaptosomal-associated protein, 25kDa
STAR steroidogenic acute regulatory protein
TARP TCR gamma alternate reading frame protein
TLR4 toll-like receptor 4
TRAC T cell receptor alpha constant
TRIM33 tripartite motif containing 33
TUBB2A tubulin, beta 2A class IIa
UGCG UDP-glucose ceramide glucosyltransferase
UPK1B uroplakin 1B
XIST X inactive specific transcript (non-protein coding)
ZBTB20 zinc finger and BTB domain containing 20
ZMYND8 zinc finger, MYND-type containing 8
Funding