BRD-K95858622_NCGC00182609-01_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K95858622_NCGC00182609-01_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ANPEP alanyl (membrane) aminopeptidase
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C6ORF62 chromosome 6 open reading frame 62
CCL5 chemokine (C-C motif) ligand 5
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL6A1 collagen, type VI, alpha 1
CSTA cystatin A (stefin A)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GRB14 growth factor receptor-bound protein 14
GSTA1 glutathione S-transferase alpha 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IL1RN interleukin 1 receptor antagonist
KRT14 keratin 14, type I
KRT19 keratin 19, type I
LCN2 lipocalin 2
LTF lactotransferrin
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
METTL7A methyltransferase like 7A
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLTP phospholipid transfer protein
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SOX4 SRY (sex determining region Y)-box 4
TOB1 transducer of ERBB2, 1
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TWIST1 twist family bHLH transcription factor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADAM10 ADAM metallopeptidase domain 10
AMIGO2 adhesion molecule with Ig-like domain 2
ARFIP2 ADP-ribosylation factor interacting protein 2
ATR ATR serine/threonine kinase
BRCA1 breast cancer 1, early onset
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CEMIP cell migration inducing protein, hyaluronan binding
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM208A family with sequence similarity 208, member A
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
HMGA2 high mobility group AT-hook 2
IFI16 interferon, gamma-inducible protein 16
KRT18 keratin 18, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MET MET proto-oncogene, receptor tyrosine kinase
MTCL1 microtubule crosslinking factor 1
MTDH metadherin
MYH10 myosin, heavy chain 10, non-muscle
MYOF myoferlin
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
RNMT RNA (guanine-7-) methyltransferase
RPA2 replication protein A2, 32kDa
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TCERG1 transcription elongation regulator 1
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TRIP6 thyroid hormone receptor interactor 6
UBR4 ubiquitin protein ligase E3 component n-recognin 4
ZMYM2 zinc finger, MYM-type 2
Funding