BRD-K96147838_5-bromo-2-(4-(tert-butyl)benzamido)-4-chlorobenzoic acid KUC107591N_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-K96147838_5-bromo-2-(4-(tert-butyl)benzamido)-4-chlorobenzoic acid KUC107591N_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COMP cartilage oligomeric matrix protein
DDIT4 DNA-damage-inducible transcript 4
EPAS1 endothelial PAS domain protein 1
FBN2 fibrillin 2
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA8B golgin A8 family, member B
HMOX1 heme oxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
JUNB jun B proto-oncogene
KRT14 keratin 14, type I
KRT17 keratin 17, type I
L1CAM L1 cell adhesion molecule
LCN2 lipocalin 2
MARS methionyl-tRNA synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RTN2 reticulon 2
SARS seryl-tRNA synthetase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TRIB3 tribbles pseudokinase 3
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
ETV1 ets variant 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
LYN LYN proto-oncogene, Src family tyrosine kinase
MARCKS myristoylated alanine-rich protein kinase C substrate
NR2F2 nuclear receptor subfamily 2, group F, member 2
PER2 period circadian clock 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RPA3 replication protein A3, 14kDa
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TUBA1A tubulin, alpha 1a
ZW10 zw10 kinetochore protein
Funding