BRD-K96433222_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K96433222_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
ASRGL1 asparaginase like 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BMP4 bone morphogenetic protein 4
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CALML4 calmodulin-like 4
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CYTIP cytohesin 1 interacting protein
DUSP6 dual specificity phosphatase 6
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
MAP7 microtubule-associated protein 7
MGP matrix Gla protein
MYH11 myosin, heavy chain 11, smooth muscle
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PBX1 pre-B-cell leukemia homeobox 1
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PPOX protoporphyrinogen oxidase
PRAME preferentially expressed antigen in melanoma
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFRP1 secreted frizzled-related protein 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SPRED2 sprouty-related, EVH1 domain containing 2
SSBP2 single-stranded DNA binding protein 2
TBX3 T-box 3
TPM2 tropomyosin 2 (beta)
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican

decreased expression

Symbol Name
CD47 CD47 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DICER1 dicer 1, ribonuclease type III
EFNB2 ephrin-B2
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GOLGA8A golgin A8 family, member A
HLTF helicase-like transcription factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IL6R interleukin 6 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
LAGE3 L antigen family, member 3
LTBP3 latent transforming growth factor beta binding protein 3
NOTCH2NL notch 2 N-terminal like
PI3 peptidase inhibitor 3, skin-derived
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTGES prostaglandin E synthase
RPS11 ribosomal protein S11
RUNX1 runt-related transcription factor 1
SPRR2B small proline-rich protein 2B
TFF1 trefoil factor 1
TNC tenascin C
UGCG UDP-glucose ceramide glucosyltransferase