BRD-K96621343_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K96621343_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ALOX5 arachidonate 5-lipoxygenase
ANO1 anoctamin 1, calcium activated chloride channel
AQP1 aquaporin 1 (Colton blood group)
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
C3AR1 complement component 3a receptor 1
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
CSTB cystatin B (stefin B)
CTGF connective tissue growth factor
CTSB cathepsin B
CXCR4 chemokine (C-X-C motif) receptor 4
CYTIP cytohesin 1 interacting protein
EMP1 epithelial membrane protein 1
FOLR1 folate receptor 1 (adult)
FXYD5 FXYD domain containing ion transport regulator 5
GMPR guanosine monophosphate reductase
HOXB2 homeobox B2
HOXB6 homeobox B6
IFI16 interferon, gamma-inducible protein 16
IGFBP6 insulin-like growth factor binding protein 6
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
KLK10 kallikrein-related peptidase 10
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
MALL mal, T-cell differentiation protein-like
MET MET proto-oncogene, receptor tyrosine kinase
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCOLCE procollagen C-endopeptidase enhancer
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PODXL podocalyxin-like
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
RNASET2 ribonuclease T2
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SFRP4 secreted frizzled-related protein 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNAI2 snail family zinc finger 2
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TTC3 tetratricopeptide repeat domain 3
VSNL1 visinin-like 1
WFDC2 WAP four-disulfide core domain 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
BEX1 brain expressed, X-linked 1
BZW2 basic leucine zipper and W2 domains 2
DLC1 DLC1 Rho GTPase activating protein
EIF5 eukaryotic translation initiation factor 5
ENO1 enolase 1, (alpha)
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA3 GATA binding protein 3
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPH1 heat shock 105kDa/110kDa protein 1
N4BP2L2 NEDD4 binding protein 2-like 2
NPEPL1 aminopeptidase-like 1
NPY1R neuropeptide Y receptor Y1
PCCB propionyl CoA carboxylase, beta polypeptide
PDLIM5 PDZ and LIM domain 5
PWP1 PWP1 homolog (S. cerevisiae)
RAD51C RAD51 paralog C
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TDG thymine-DNA glycosylase
TXNL4B thioredoxin-like 4B
VDAC1 voltage-dependent anion channel 1