BRD-K96778649_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K96778649_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
BPGM 2,3-bisphosphoglycerate mutase
CA2 carbonic anhydrase II
CD59 CD59 molecule, complement regulatory protein
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLCA4 chloride channel accessory 4
CLIC4 chloride intracellular channel 4
COCH cochlin
CTTN cortactin
CXCL5 chemokine (C-X-C motif) ligand 5
GPM6B glycoprotein M6B
GUSBP11 glucuronidase, beta pseudogene 11
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MIR22HG MIR22 host gene
MMD monocyte to macrophage differentiation-associated
NPTX2 neuronal pentraxin II
PIP prolactin-induced protein
PLAGL1 pleiomorphic adenoma gene-like 1
PRDX1 peroxiredoxin 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RBPMS RNA binding protein with multiple splicing
RNASE4 ribonuclease, RNase A family, 4
RTN4 reticulon 4
S100P S100 calcium binding protein P
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX11 sorting nexin 11
TOX3 TOX high mobility group box family member 3
TUBB2A tubulin, beta 2A class IIa
VAT1 vesicle amine transport 1
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
CADM1 cell adhesion molecule 1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH3 cadherin 3, type 1, P-cadherin (placental)
CPVL carboxypeptidase, vitellogenic-like
DTX4 deltex 4, E3 ubiquitin ligase
EMP2 epithelial membrane protein 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FSD1 fibronectin type III and SPRY domain containing 1
G0S2 G0/G1 switch 2
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
IFI16 interferon, gamma-inducible protein 16
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
VAV3 vav 3 guanine nucleotide exchange factor
XIST X inactive specific transcript (non-protein coding)
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