BRD-K96799727_-666_A673_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K96799727_-666_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BTG2 BTG family, member 2
C1S complement component 1, s subcomponent
C20ORF24 chromosome 20 open reading frame 24
CBR3 carbonyl reductase 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
CLU clusterin
COCH cochlin
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGF epidermal growth factor
EGR1 early growth response 1
EHF ets homologous factor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPHA3 EPH receptor A3
F3 coagulation factor III (thromboplastin, tissue factor)
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IARS isoleucyl-tRNA synthetase
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF4 Kruppel-like factor 4 (gut)
LOC100505650 uncharacterized LOC100505650
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP10 matrix metallopeptidase 10
MSMB microseminoprotein, beta-
MT1M metallothionein 1M
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP50 nucleoporin 50kDa
PELI2 pellino E3 ubiquitin protein ligase family member 2
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
S100A2 S100 calcium binding protein A2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TALDO1 transaldolase 1
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TRIB1 tribbles pseudokinase 1
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UBXN4 UBX domain protein 4
WARS tryptophanyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTG2 actin, gamma 2, smooth muscle, enteric
AKAP13 A kinase (PRKA) anchor protein 13
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARMCX2 armadillo repeat containing, X-linked 2
ASPH aspartate beta-hydroxylase
BCHE butyrylcholinesterase
BCL2A1 BCL2-related protein A1
CCL20 chemokine (C-C motif) ligand 20
CCNF cyclin F
CD81 CD81 molecule
CDC20 cell division cycle 20
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
DGKZ diacylglycerol kinase, zeta
DHCR24 24-dehydrocholesterol reductase
EFNB2 ephrin-B2
FABP4 fatty acid binding protein 4, adipocyte
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GOLGA8A golgin A8 family, member A
GREM1 gremlin 1, DAN family BMP antagonist
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INHBB inhibin, beta B
IRS1 insulin receptor substrate 1
ITM2A integral membrane protein 2A
KIF2C kinesin family member 2C
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
METRN meteorin, glial cell differentiation regulator
MFSD10 major facilitator superfamily domain containing 10
MMP9 matrix metallopeptidase 9
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAV2 neuron navigator 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PI3 peptidase inhibitor 3, skin-derived
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
SCG5 secretogranin V
SH3BGRL SH3 domain binding glutamate-rich protein like
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TM4SF4 transmembrane 4 L six family member 4
TPM2 tropomyosin 2 (beta)
TRIB2 tribbles pseudokinase 2
TSPAN12 tetraspanin 12
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
Funding