BRD-K97274161_N-{2-[benzyl(isopropyl)amino]ethyl}-4-({[(4-methylphenyl)sulfonyl]amino}methyl)benzamide_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K97274161_N-{2-[benzyl(isopropyl)amino]ethyl}-4-({[(4-methylphenyl)sulfonyl]amino}methyl)benzamide_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
ALDOC aldolase C, fructose-bisphosphate
ASCL1 achaete-scute family bHLH transcription factor 1
BZW2 basic leucine zipper and W2 domains 2
CD47 CD47 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CNOT4 CCR4-NOT transcription complex, subunit 4
COMP cartilage oligomeric matrix protein
CTSK cathepsin K
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DHCR7 7-dehydrocholesterol reductase
ELOVL6 ELOVL fatty acid elongase 6
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MID1 midline 1
MSMO1 methylsterol monooxygenase 1
MSRB2 methionine sulfoxide reductase B2
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
MYLK myosin light chain kinase
NT5E 5'-nucleotidase, ecto (CD73)
PDGFC platelet derived growth factor C
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POPDC3 popeye domain containing 3
PTK2 protein tyrosine kinase 2
PTPRK protein tyrosine phosphatase, receptor type, K
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SQLE squalene epoxidase
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17A serine/threonine kinase 17a
TGFBI transforming growth factor, beta-induced, 68kDa
TMCC1 transmembrane and coiled-coil domain family 1
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
C8ORF4 chromosome 8 open reading frame 4
CA2 carbonic anhydrase II
DACH1 dachshund family transcription factor 1
E2F2 E2F transcription factor 2
ELANE elastase, neutrophil expressed
FBP1 fructose-1,6-bisphosphatase 1
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
IGHM immunoglobulin heavy constant mu
KRT18 keratin 18, type I
MUC4 mucin 4, cell surface associated
RAD23B RAD23 homolog B (S. cerevisiae)
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RTN1 reticulon 1
SCGB2A2 secretoglobin, family 2A, member 2
TACSTD2 tumor-associated calcium signal transducer 2
TCL1A T-cell leukemia/lymphoma 1A
TFF1 trefoil factor 1
XIST X inactive specific transcript (non-protein coding)
Funding