BRD-K97365803_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K97365803_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAST calpastatin
CCNG2 cyclin G2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK19 cyclin-dependent kinase 19
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CNPY3 canopy FGF signaling regulator 3
COL1A1 collagen, type I, alpha 1
DUOX2 dual oxidase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EVI2A ecotropic viral integration site 2A
FZD5 frizzled class receptor 5
GALC galactosylceramidase
GSDMB gasdermin B
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LGALS8 lectin, galactoside-binding, soluble, 8
LYST lysosomal trafficking regulator
MCTP1 multiple C2 domains, transmembrane 1
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
MYOF myoferlin
NEB nebulin
NT5E 5'-nucleotidase, ecto (CD73)
NXN nucleoredoxin
PBX3 pre-B-cell leukemia homeobox 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
TKTL1 transketolase-like 1
TTN titin
TXNIP thioredoxin interacting protein
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK1 adenylate kinase 1
AMD1 adenosylmethionine decarboxylase 1
ARPC5L actin related protein 2/3 complex, subunit 5-like
C1S complement component 1, s subcomponent
C20ORF24 chromosome 20 open reading frame 24
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
CCL19 chemokine (C-C motif) ligand 19
CCL21 chemokine (C-C motif) ligand 21
CD69 CD69 molecule
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L2 chitinase 3-like 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FADS1 fatty acid desaturase 1
G0S2 G0/G1 switch 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNAS GNAS complex locus
GRWD1 glutamate-rich WD repeat containing 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
KRT7 keratin 7, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTF lactotransferrin
MSLN mesothelin
MTDH metadherin
MXRA7 matrix-remodelling associated 7
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY1R neuropeptide Y receptor Y1
NUP98 nucleoporin 98kDa
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PPIF peptidylprolyl isomerase F
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RGS1 regulator of G-protein signaling 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT9 septin 9
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SRSF2 serine/arginine-rich splicing factor 2
TFRC transferrin receptor
TUBA4A tubulin, alpha 4a
Funding