BRD-K97399794_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K97399794_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AMOTL2 angiomotin like 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CXADR coxsackie virus and adenovirus receptor
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
ENO2 enolase 2 (gamma, neuronal)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GPM6B glycoprotein M6B
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IDO1 indoleamine 2,3-dioxygenase 1
LARP6 La ribonucleoprotein domain family, member 6
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDRG1 N-myc downstream regulated 1
NUAK1 NUAK family, SNF1-like kinase, 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDE4DIP phosphodiesterase 4D interacting protein
PHGDH phosphoglycerate dehydrogenase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RBM8A RNA binding motif protein 8A
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SESN1 sestrin 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TDP2 tyrosyl-DNA phosphodiesterase 2
TMEM176B transmembrane protein 176B
TP53 tumor protein p53
TRIM22 tripartite motif containing 22
TXNRD1 thioredoxin reductase 1
UBE3B ubiquitin protein ligase E3B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFM1 ubiquitin-fold modifier 1
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKAP4 cytoskeleton-associated protein 4
CKS2 CDC28 protein kinase regulatory subunit 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CTSH cathepsin H
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FAR2 fatty acyl CoA reductase 2
GALE UDP-galactose-4-epimerase
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPSM2 G-protein signaling modulator 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KIAA0922 KIAA0922
KIF14 kinesin family member 14
KIF23 kinesin family member 23
LCN2 lipocalin 2
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MSH6 mutS homolog 6
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
S100A7 S100 calcium binding protein A7
SOX11 SRY (sex determining region Y)-box 11
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TTK TTK protein kinase
UBE3C ubiquitin protein ligase E3C
Funding