BRD-K97534490_-666_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K97534490_-666_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTC1 actin, alpha, cardiac muscle 1
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DMBT1 deleted in malignant brain tumors 1
DSP desmoplakin
EDN3 endothelin 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
HEPH hephaestin
HYOU1 hypoxia up-regulated 1
IL32 interleukin 32
INHBA inhibin, beta A
ITGAV integrin, alpha V
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
LCN2 lipocalin 2
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NDRG1 N-myc downstream regulated 1
OXSR1 oxidative stress responsive 1
P3H2 prolyl 3-hydroxylase 2
PDZK1IP1 PDZK1 interacting protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RGS1 regulator of G-protein signaling 1
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SLC38A1 solute carrier family 38, member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TPM4 tropomyosin 4
TRPS1 trichorhinophalangeal syndrome I
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
B3GNT1
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDK4 cyclin-dependent kinase 4
CKS2 CDC28 protein kinase regulatory subunit 2
ELP5 elongator acetyltransferase complex subunit 5
ETV1 ets variant 1
GNPDA1 glucosamine-6-phosphate deaminase 1
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXC6 homeobox C6
LIG1 ligase I, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
MATN2 matrilin 2
MCM2 minichromosome maintenance complex component 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCNA proliferating cell nuclear antigen
PRNP prion protein
PSENEN presenilin enhancer gamma secretase subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TMEM97 transmembrane protein 97
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TYMS thymidylate synthetase
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