BRD-K97936712_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K97936712_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EHD4 EH-domain containing 4
EMP1 epithelial membrane protein 1
FAM46A family with sequence similarity 46, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HCAR3 hydroxycarboxylic acid receptor 3
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RHOB ras homolog family member B
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
STC2 stanniocalcin 2
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
CANT1 calcium activated nucleotidase 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
DUSP22 dual specificity phosphatase 22
EIF5 eukaryotic translation initiation factor 5
FASTKD5 FAST kinase domains 5
FNBP1 formin binding protein 1
FUBP1 far upstream element (FUSE) binding protein 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HMGB3 high mobility group box 3
HMGN3 high mobility group nucleosomal binding domain 3
HSPA8 heat shock 70kDa protein 8
KIF20A kinesin family member 20A
LPCAT1 lysophosphatidylcholine acyltransferase 1
LUM lumican
MAT2A methionine adenosyltransferase II, alpha
METTL3 methyltransferase like 3
PARP2 poly (ADP-ribose) polymerase 2
PCP4 Purkinje cell protein 4
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PRKCA protein kinase C, alpha
RPS11 ribosomal protein S11
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TNNT1 troponin T type 1 (skeletal, slow)
TRAPPC3 trafficking protein particle complex 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTF1 transcription termination factor, RNA polymerase I
VIM vimentin
ZNF302 zinc finger protein 302
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