BRD-K98490050_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

232 genes differentially expressed following the BRD-K98490050_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EHD1 EH-domain containing 1
FAS Fas cell surface death receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
IL6 interleukin 6
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MT1E metallothionein 1E
MYB v-myb avian myeloblastosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OPTN optineurin
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTX3 pentraxin 3, long
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RRAD Ras-related associated with diabetes
SAMD4A sterile alpha motif domain containing 4A
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TNF tumor necrosis factor
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TRAF1 TNF receptor-associated factor 1
VCAM1 vascular cell adhesion molecule 1
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRG2 adhesion G protein-coupled receptor G2
AGTR1 angiotensin II receptor, type 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BEX1 brain expressed, X-linked 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALD1 caldesmon 1
CAV2 caveolin 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDCA3 cell division cycle associated 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CLIC1 chloride intracellular channel 1
CLIC4 chloride intracellular channel 4
CLTC clathrin, heavy chain (Hc)
COCH cochlin
COL4A1 collagen, type IV, alpha 1
CST1 cystatin SN
CXCL14 chemokine (C-X-C motif) ligand 14
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
ECT2 epithelial cell transforming 2
EDNRB endothelin receptor type B
EPRS glutamyl-prolyl-tRNA synthetase
FOLR1 folate receptor 1 (adult)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPSM2 G-protein signaling modulator 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB7 homeobox B7
HOXC6 homeobox C6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ITGA6 integrin, alpha 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
MACF1 microtubule-actin crosslinking factor 1
MAP1B microtubule-associated protein 1B
MBNL1 muscleblind-like splicing regulator 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MPZL1 myelin protein zero-like 1
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NTS neurotensin
PBK PDZ binding kinase
PCSK1 proprotein convertase subtilisin/kexin type 1
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PRSS23 protease, serine, 23
RHOBTB3 Rho-related BTB domain containing 3
RPS11 ribosomal protein S11
RTN1 reticulon 1
S100P S100 calcium binding protein P
SAP30 Sin3A-associated protein, 30kDa
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SPC25 SPC25, NDC80 kinetochore complex component
SPTBN1 spectrin, beta, non-erythrocytic 1
SSFA2 sperm specific antigen 2
SYT1 synaptotagmin I
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TKT transketolase
TMEM47 transmembrane protein 47
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TSPAN13 tetraspanin 13
TTK TTK protein kinase
VCAN versican
ZBTB38 zinc finger and BTB domain containing 38
ZMYND8 zinc finger, MYND-type containing 8