BRD-K98490050_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-K98490050_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ADM adrenomedullin
AK1 adenylate kinase 1
AREG amphiregulin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BTG2 BTG family, member 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC11A C-type lectin domain family 11, member A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP14 dual specificity phosphatase 14
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FAM107A family with sequence similarity 107, member A
FAS Fas cell surface death receptor
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6B glycoprotein M6B
HBB hemoglobin, beta
HOXA5 homeobox A5
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
INPP1 inositol polyphosphate-1-phosphatase
KRT17 keratin 17, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MIR22HG MIR22 host gene
PEG3 paternally expressed 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
RND3 Rho family GTPase 3
RNF6 ring finger protein (C3H2C3 type) 6
RPS27L ribosomal protein S27-like
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TBPL1 TBP-like 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFA transforming growth factor, alpha
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
ZBTB18 zinc finger and BTB domain containing 18
ZBTB43 zinc finger and BTB domain containing 43
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMBP alpha-1-microglobulin/bikunin precursor
ANXA4 annexin A4
ANXA7 annexin A7
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOH apolipoprotein H (beta-2-glycoprotein I)
APOM apolipoprotein M
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BIRC5 baculoviral IAP repeat containing 5
C2CD5 C2 calcium-dependent domain containing 5
C4BPA complement component 4 binding protein, alpha
C5 complement component 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25B cell division cycle 25B
CDK4 cyclin-dependent kinase 4
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFB complement factor B
CFH complement factor H
CTSH cathepsin H
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
EPRS glutamyl-prolyl-tRNA synthetase
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGF13 fibroblast growth factor 13
FGG fibrinogen gamma chain
FGL1 fibrinogen-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GMDS GDP-mannose 4,6-dehydratase
GPC3 glypican 3
HACD2 3-hydroxyacyl-CoA dehydratase 2
HMGA2 high mobility group AT-hook 2
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFITM2 interferon induced transmembrane protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP1 insulin-like growth factor binding protein 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIF14 kinesin family member 14
KRT81 keratin 81, type II
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LIMS1 LIM and senescent cell antigen-like domains 1
LPP LIM domain containing preferred translocation partner in lipoma
MACF1 microtubule-actin crosslinking factor 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MPZL1 myelin protein zero-like 1
MTUS1 microtubule associated tumor suppressor 1
MYO5C myosin VC
NID2 nidogen 2 (osteonidogen)
NR2F2 nuclear receptor subfamily 2, group F, member 2
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PDGFD platelet derived growth factor D
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PHKB phosphorylase kinase, beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PRDX1 peroxiredoxin 1
PROS1 protein S (alpha)
PSAP prosaposin
PSPH phosphoserine phosphatase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELN reelin
RHOBTB3 Rho-related BTB domain containing 3
RNASE4 ribonuclease, RNase A family, 4
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TCF12 transcription factor 12
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM123 transmembrane protein 123
TMEM14A transmembrane protein 14A
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TUBB tubulin, beta class I
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
Funding