BRD-K98676510_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-pyridin-2-ylthiophene-2-sulfonamide_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

275 genes differentially expressed following the BRD-K98676510_N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-5-pyridin-2-ylthiophene-2-sulfonamide_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD3 abhydrolase domain containing 3
ACAT1 acetyl-CoA acetyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ADA adenosine deaminase
ADCY9 adenylate cyclase 9
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ANXA6 annexin A6
AOX1 aldehyde oxidase 1
ARHGAP29 Rho GTPase activating protein 29
ASMTL acetylserotonin O-methyltransferase-like
ATG2A autophagy related 2A
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALCOCO2 calcium binding and coiled-coil domain 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CETN2 centrin, EF-hand protein, 2
CGRRF1 cell growth regulator with ring finger domain 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CIB1 calcium and integrin binding 1 (calmyrin)
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CTH cystathionine gamma-lyase
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSTN destrin (actin depolymerizing factor)
ECHDC3 enoyl CoA hydratase domain containing 3
ECI2 enoyl-CoA delta isomerase 2
ELOVL5 ELOVL fatty acid elongase 5
ENAH enabled homolog (Drosophila)
EZR ezrin
FADS1 fatty acid desaturase 1
FBXO2 F-box protein 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GMCL1 germ cell-less, spermatogenesis associated 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPX3 glutathione peroxidase 3
GUK1 guanylate kinase 1
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IL32 interleukin 32
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KCTD5 potassium channel tetramerization domain containing 5
LGMN legumain
LINC00094 long intergenic non-protein coding RNA 94
LIPA lipase A, lysosomal acid, cholesterol esterase
LITAF lipopolysaccharide-induced TNF factor
LPIN1 lipin 1
LTA4H leukotriene A4 hydrolase
MAGEB2 melanoma antigen family B2
MAGED1 melanoma antigen family D1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
METRN meteorin, glial cell differentiation regulator
MICB MHC class I polypeptide-related sequence B
MLF1 myeloid leukemia factor 1
MPC1 mitochondrial pyruvate carrier 1
MPZL1 myelin protein zero-like 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MXRA7 matrix-remodelling associated 7
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDRG3 NDRG family member 3
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NEU1 sialidase 1 (lysosomal sialidase)
NME5 NME/NM23 family member 5
NME7 NME/NM23 family member 7
NMT2 N-myristoyltransferase 2
NOSIP nitric oxide synthase interacting protein
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
OPTN optineurin
OSBPL8 oxysterol binding protein-like 8
OSTM1 osteopetrosis associated transmembrane protein 1
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDLIM2 PDZ and LIM domain 2 (mystique)
PHGDH phosphoglycerate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
PNMA2 paraneoplastic Ma antigen 2
PRDX1 peroxiredoxin 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RFK riboflavin kinase
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RIMS3 regulating synaptic membrane exocytosis 3
RIOK3 RIO kinase 3
ROGDI rogdi homolog (Drosophila)
RRAGD Ras-related GTP binding D
RTN3 reticulon 3
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SEPHS2 selenophosphate synthetase 2
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNAP23 synaptosomal-associated protein, 23kDa
SNN stannin
SORBS3 sorbin and SH3 domain containing 3
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBPL1 TBP-like 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TPST2 tyrosylprotein sulfotransferase 2
TRAK2 trafficking protein, kinesin binding 2
TSC22D3 TSC22 domain family, member 3
TSNAX translin-associated factor X
TSPAN4 tetraspanin 4
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VAMP7 vesicle-associated membrane protein 7
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AIM2 absent in melanoma 2
ANXA10 annexin A10
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CLEC5A C-type lectin domain family 5, member A
COL4A6 collagen, type IV, alpha 6
COMT catechol-O-methyltransferase
CPA3 carboxypeptidase A3 (mast cell)
CST7 cystatin F (leukocystatin)
CTSE cathepsin E
CXCL11 chemokine (C-X-C motif) ligand 11
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DENND2D DENN/MADD domain containing 2D
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EREG epiregulin
F5 coagulation factor V (proaccelerin, labile factor)
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
FST follistatin
GPR171 G protein-coupled receptor 171
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GTF2I general transcription factor IIi
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAS2 hyaluronan synthase 2
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
IGHM immunoglobulin heavy constant mu
IRAK1 interleukin-1 receptor-associated kinase 1
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KRT13 keratin 13, type I
KRT15 keratin 15, type I
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LCN2 lipocalin 2
LMNB2 lamin B2
LTF lactotransferrin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MCTP1 multiple C2 domains, transmembrane 1
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MPZL2 myelin protein zero-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NOP16 NOP16 nucleolar protein
OBSL1 obscurin-like 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCDH7 protocadherin 7
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
PSCA prostate stem cell antigen
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL10 ribosomal protein L10
RTP4 receptor (chemosensory) transporter protein 4
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC35F2 solute carrier family 35, member F2
SMAGP small cell adhesion glycoprotein
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP3 STEAP family member 3, metalloreductase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TCERG1 transcription elongation regulator 1
TDO2 tryptophan 2,3-dioxygenase
TFF1 trefoil factor 1
TMPRSS4 transmembrane protease, serine 4
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TTC39A tetratricopeptide repeat domain 39A
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2
Funding