BRD-K98731749_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K98731749_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADM adrenomedullin
ANKRD10 ankyrin repeat domain 10
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CA1 carbonic anhydrase I
CANX calnexin
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FXYD3 FXYD domain containing ion transport regulator 3
GARS glycyl-tRNA synthetase
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IFI30 interferon, gamma-inducible protein 30
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
LY96 lymphocyte antigen 96
MARS methionyl-tRNA synthetase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
SARS seryl-tRNA synthetase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TGIF1 TGFB-induced factor homeobox 1
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
COL2A1 collagen, type II, alpha 1
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
FGFR3 fibroblast growth factor receptor 3
GLIPR1 GLI pathogenesis-related 1
IFI6 interferon, alpha-inducible protein 6
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
NPTX2 neuronal pentraxin II
PBLD phenazine biosynthesis-like protein domain containing
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS2 regulator of G-protein signaling 2
UBE3B ubiquitin protein ligase E3B