BRD-K99252563_QL-XII-47_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K99252563_QL-XII-47_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT9 acyl-CoA thioesterase 9
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANO1 anoctamin 1, calcium activated chloride channel
ANXA3 annexin A3
ARL4C ADP-ribosylation factor-like 4C
BAG3 BCL2-associated athanogene 3
CCL2 chemokine (C-C motif) ligand 2
CCNA1 cyclin A1
CDCP1 CUB domain containing protein 1
CLC Charcot-Leyden crystal galectin
CLGN calmegin
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
FOSL1 FOS-like antigen 1
GPNMB glycoprotein (transmembrane) nmb
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
LAMC2 laminin, gamma 2
LAMP1 lysosomal-associated membrane protein 1
LIF leukemia inhibitory factor
LYRM1 LYR motif containing 1
MGLL monoglyceride lipase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYOF myoferlin
PFN2 profilin 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAU plasminogen activator, urokinase
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTN pleiotrophin
S100A2 S100 calcium binding protein A2
SAMD4A sterile alpha motif domain containing 4A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
TACSTD2 tumor-associated calcium signal transducer 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNPO1 transportin 1
VEGFA vascular endothelial growth factor A
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
AXIN1 axin 1
C5 complement component 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND3 cyclin D3
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL5A2 collagen, type V, alpha 2
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPX3 glutathione peroxidase 3
H1FX H1 histone family, member X
IFITM1 interferon induced transmembrane protein 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLF2 Kruppel-like factor 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NET1 neuroepithelial cell transforming 1
NTS neurotensin
OAT ornithine aminotransferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBP4 retinol binding protein 4, plasma
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
STK10 serine/threonine kinase 10
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TSPAN13 tetraspanin 13
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
Funding