BRD-K99252563_QL-XII-47_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

388 genes differentially expressed following the BRD-K99252563_QL-XII-47_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C3 aldo-keto reductase family 1, member C3
ANGPT1 angiopoietin 1
ANKRD10 ankyrin repeat domain 10
ANKRD28 ankyrin repeat domain 28
ANXA2 annexin A2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL8B ADP-ribosylation factor-like 8B
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF7IP activating transcription factor 7 interacting protein
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
AZU1 azurocidin 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELF2 CUGBP, Elav-like family member 2
CHD1 chromodomain helicase DNA binding protein 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN10 claudin 10
CLK4 CDC-like kinase 4
COL11A1 collagen, type XI, alpha 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CST1 cystatin SN
CST2 cystatin SA
CST4 cystatin S
CTBS chitobiase, di-N-acetyl-
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYBRD1 cytochrome b reductase 1
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DLX2 distal-less homeobox 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EAPP E2F-associated phosphoprotein
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR3 early growth response 3
EP300 E1A binding protein p300
EPCAM epithelial cell adhesion molecule
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FAM63A family with sequence similarity 63, member A
FAM8A1 family with sequence similarity 8, member A1
FEM1C fem-1 homolog c (C. elegans)
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATAD1 GATA zinc finger domain containing 1
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GTF2B general transcription factor IIB
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL6R interleukin 6 receptor
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2A integral membrane protein 2A
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KLF10 Kruppel-like factor 10
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHDC2 kelch domain containing 2
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KYNU kynureninase
LACTB2 lactamase, beta 2
LGALS3 lectin, galactoside-binding, soluble, 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MBNL2 muscleblind-like splicing regulator 2
MED13L mediator complex subunit 13-like
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NCOA2 nuclear receptor coactivator 2
NEFL neurofilament, light polypeptide
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFE2L2 nuclear factor, erythroid 2-like 2
NGDN neuroguidin, EIF4E binding protein
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSER1 oxidative stress responsive serine-rich 1
PDLIM4 PDZ and LIM domain 4
PEG3 paternally expressed 3
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER2 period circadian clock 2
PHF21A PHD finger protein 21A
PHF3 PHD finger protein 3
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLA2G16 phospholipase A2, group XVI
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLIN2 perilipin 2
PPAP2C phosphatidic acid phosphatase type 2C
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RAB9A RAB9A, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RBKS ribokinase
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RLF rearranged L-myc fusion
RNF103 ring finger protein 103
RNF13 ring finger protein 13
RNMT RNA (guanine-7-) methyltransferase
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SC5D sterol-C5-desaturase
SCYL3 SCY1-like 3 (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SERINC1 serine incorporator 1
SERTAD2 SERTA domain containing 2
SIK3 SIK family kinase 3
SIRT1 sirtuin 1
SLC16A6 solute carrier family 16, member 6
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SPG20 spastic paraplegia 20 (Troyer syndrome)
SQSTM1 sequestosome 1
STK38L serine/threonine kinase 38 like
STON1 stonin 1
STX1A syntaxin 1A (brain)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBC1D15 TBC1 domain family, member 15
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TERF2IP telomeric repeat binding factor 2, interacting protein
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFE3 transcription factor binding to IGHM enhancer 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52L1 tumor protein D52-like 1
TRH thyrotropin-releasing hormone
TRPS1 trichorhinophalangeal syndrome I
TSG101 tumor susceptibility 101
TTC17 tetratricopeptide repeat domain 17
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UBAP1 ubiquitin associated protein 1
UBE2B ubiquitin-conjugating enzyme E2B
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBXN7 UBX domain protein 7
USP15 ubiquitin specific peptidase 15
YTHDC1 YTH domain containing 1
ZBTB43 zinc finger and BTB domain containing 43
ZCCHC6 zinc finger, CCHC domain containing 6
ZFP36 ZFP36 ring finger protein
ZFR zinc finger RNA binding protein
ZMYM2 zinc finger, MYM-type 2
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABR active BCR-related
ADAM10 ADAM metallopeptidase domain 10
ADAMDEC1 ADAM-like, decysin 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AURKA aurora kinase A
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
C1ORF116 chromosome 1 open reading frame 116
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALU calumenin
CCNA2 cyclin A2
CCNG1 cyclin G1
CD24 CD24 molecule
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CLCA4 chloride channel accessory 4
CLIC3 chloride intracellular channel 3
CRABP2 cellular retinoic acid binding protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EFCAB14 EF-hand calcium binding domain 14
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EPAS1 endothelial PAS domain protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM127A family with sequence similarity 127, member A
FAM20B family with sequence similarity 20, member B
FAM3C family with sequence similarity 3, member C
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOXM1 forkhead box M1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GTSE1 G-2 and S-phase expressed 1
HADH hydroxyacyl-CoA dehydrogenase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP5 insulin-like growth factor binding protein 5
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JCHAIN joining chain of multimeric IgA and IgM
KAZN kazrin, periplakin interacting protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIF20A kinesin family member 20A
KRT4 keratin 4, type II
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB1 lamin B1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPCAT4 lysophosphatidylcholine acyltransferase 4
LPL lipoprotein lipase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MCM4 minichromosome maintenance complex component 4
MGP matrix Gla protein
MPRIP myosin phosphatase Rho interacting protein
MPZL2 myelin protein zero-like 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPG2 non-SMC condensin II complex, subunit G2
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NEK2 NIMA-related kinase 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NXN nucleoredoxin
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKM pyruvate kinase, muscle
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SEPT11 septin 11
SEPW1 selenoprotein W, 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF5 serine/arginine-rich splicing factor 5
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCF4 transcription factor 4
TFDP1 transcription factor Dp-1
TFPI2 tissue factor pathway inhibitor 2
TIMELESS timeless circadian clock
TKT transketolase
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAK2 trafficking protein, kinesin binding 2
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TTC3 tetratricopeptide repeat domain 3
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TWF2 twinfilin actin binding protein 2
TYMS thymidylate synthetase
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UPK1B uroplakin 1B
Funding