BRD-K99252563_QL-XII-47_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K99252563_QL-XII-47_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
ATP8B4 ATPase, class I, type 8B, member 4
BIRC3 baculoviral IAP repeat containing 3
C1ORF106 chromosome 1 open reading frame 106
CA2 carbonic anhydrase II
CDCP1 CUB domain containing protein 1
COL6A1 collagen, type VI, alpha 1
FERMT1 fermitin family member 1
GPX2 glutathione peroxidase 2
H3F3B H3 histone, family 3B (H3.3B)
HSPA1A heat shock 70kDa protein 1A
IGHD immunoglobulin heavy constant delta
IRS2 insulin receptor substrate 2
KRT81 keratin 81, type II
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
NT5E 5'-nucleotidase, ecto (CD73)
PLK1 polo-like kinase 1
PODXL podocalyxin-like
REG1A regenerating islet-derived 1 alpha
SYNM synemin, intermediate filament protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CLU clusterin
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FNBP1L formin binding protein 1-like
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL1 lysyl oxidase-like 1
LRRC17 leucine rich repeat containing 17
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NSDHL NAD(P) dependent steroid dehydrogenase-like
OPN3 opsin 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDLIM1 PDZ and LIM domain 1
PHGDH phosphoglycerate dehydrogenase
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
TMEM14A transmembrane protein 14A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT5A wingless-type MMTV integration site family, member 5A
Funding