BRD-K99252563_QL-XII-47_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K99252563_QL-XII-47_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA4 annexin A4
AQP9 aquaporin 9
ARMCX2 armadillo repeat containing, X-linked 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BLNK B-cell linker
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD14 CD14 molecule
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP57 centrosomal protein 57kDa
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLU clusterin
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CXCR4 chemokine (C-X-C motif) receptor 4
DENND2D DENN/MADD domain containing 2D
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FCGBP Fc fragment of IgG binding protein
FPR1 formyl peptide receptor 1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPX4 glutathione peroxidase 4
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IL1B interleukin 1, beta
INHBB inhibin, beta B
INSIG2 insulin induced gene 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT6B keratin 6B, type II
KYNU kynureninase
LAMC2 laminin, gamma 2
LAPTM5 lysosomal protein transmembrane 5
LDOC1 leucine zipper, down-regulated in cancer 1
LPAR1 lysophosphatidic acid receptor 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP1 latent transforming growth factor beta binding protein 1
LY96 lymphocyte antigen 96
MMD monocyte to macrophage differentiation-associated
MXRA5 matrix-remodelling associated 5
MYO6 myosin VI
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
OPTN optineurin
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAM peptidylglycine alpha-amidating monooxygenase
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRAF2 PRA1 domain family, member 2
PYCARD PYD and CARD domain containing
RABAC1 Rab acceptor 1 (prenylated)
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SHB Src homology 2 domain containing adaptor protein B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A18 solute carrier family 22, member 18
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SNAI2 snail family zinc finger 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SYT17 synaptotagmin XVII
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
TRIM16 tripartite motif containing 16
TUBB2A tubulin, beta 2A class IIa
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
WNT5A wingless-type MMTV integration site family, member 5A
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPN centromere protein N
CENPU centromere protein U
CHGB chromogranin B
CSRP2 cysteine and glycine-rich protein 2
DBF4 DBF4 zinc finger
DHRS2 dehydrogenase/reductase (SDR family) member 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDNRB endothelin receptor type B
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GREB1 growth regulation by estrogen in breast cancer 1
HIST1H2BG histone cluster 1, H2bg
HMGB2 high mobility group box 2
HOXC6 homeobox C6
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NFIB nuclear factor I/B
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
PBK PDZ binding kinase
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PODXL podocalyxin-like
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU4F1 POU class 4 homeobox 1
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKD3 protein kinase D3
PSAT1 phosphoserine aminotransferase 1
PSIP1 PC4 and SFRS1 interacting protein 1
RAD51C RAD51 paralog C
RAD9A RAD9 homolog A (S. pombe)
RFC3 replication factor C (activator 1) 3, 38kDa
RPL39L ribosomal protein L39-like
RPP25 ribonuclease P/MRP 25kDa subunit
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAP25 synaptosomal-associated protein, 25kDa
SORD sorbitol dehydrogenase
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STMN1 stathmin 1
TEX10 testis expressed 10
TFAM transcription factor A, mitochondrial
TMEM97 transmembrane protein 97
TMPO thymopoietin
UBE2S ubiquitin-conjugating enzyme E2S
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Funding