BRD-K99252563_QL-XII-47_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K99252563_QL-XII-47_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADM adrenomedullin
AREG amphiregulin
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CPE carboxypeptidase E
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DST dystonin
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FAS Fas cell surface death receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
LIF leukemia inhibitory factor
LPIN2 lipin 2
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
OGN osteoglycin
RAP1GAP RAP1 GTPase activating protein
RGS1 regulator of G-protein signaling 1
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
TFPI2 tissue factor pathway inhibitor 2
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AIM2 absent in melanoma 2
B3GNT1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLTB clathrin, light chain B
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
CRISP3 cysteine-rich secretory protein 3
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST6 cystatin E/M
CTSK cathepsin K
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLK1 delta-like 1 homolog (Drosophila)
FAM57A family with sequence similarity 57, member A
HEXB hexosaminidase B (beta polypeptide)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT23 keratin 23, type I
KRT6A keratin 6A, type II
LY6D lymphocyte antigen 6 complex, locus D
MAB21L2 mab-21-like 2 (C. elegans)
MYLK myosin light chain kinase
NPY neuropeptide Y
OAT ornithine aminotransferase
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
SERINC5 serine incorporator 5
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SNAP25 synaptosomal-associated protein, 25kDa
SPINK5 serine peptidase inhibitor, Kazal type 5
STMN2 stathmin 2
TCF4 transcription factor 4
THBS2 thrombospondin 2
TYRP1 tyrosinase-related protein 1
ZMYND8 zinc finger, MYND-type containing 8
Funding