BRD-K99252563_QL-XII-47_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K99252563_QL-XII-47_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ADCK3 aarF domain containing kinase 3
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
COL14A1 collagen, type XIV, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FBXL12 F-box and leucine-rich repeat protein 12
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IL6 interleukin 6
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KIF5C kinesin family member 5C
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAL mal, T-cell differentiation protein
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PEG3 paternally expressed 3
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RYBP RING1 and YY1 binding protein
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
TBPL1 TBP-like 1
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASRGL1 asparaginase like 1
BCHE butyrylcholinesterase
BTBD3 BTB (POZ) domain containing 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CST1 cystatin SN
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DIO2 deiodinase, iodothyronine, type II
DPY19L1 dpy-19-like 1 (C. elegans)
EDNRB endothelin receptor type B
ERBB2 erb-b2 receptor tyrosine kinase 2
FNBP1L formin binding protein 1-like
GPM6B glycoprotein M6B
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMG20B high mobility group 20B
HOXA10 homeobox A10
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
LAPTM4B lysosomal protein transmembrane 4 beta
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED1 melanoma antigen family D1
MBOAT7 membrane bound O-acyltransferase domain containing 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPR3 natriuretic peptide receptor 3
NPTX2 neuronal pentraxin II
NRIP3 nuclear receptor interacting protein 3
OPN3 opsin 3
PIR pirin (iron-binding nuclear protein)
PON2 paraoxonase 2
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSCA prostate stem cell antigen
RPA3 replication protein A3, 14kDa
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
SSFA2 sperm specific antigen 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMEM47 transmembrane protein 47
TYRP1 tyrosinase-related protein 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WRB tryptophan rich basic protein
Funding