BRD-K99252563_QL-XII-47_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K99252563_QL-XII-47_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOLD1 apolipoprotein L domain containing 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
C9ORF3 chromosome 9 open reading frame 3
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL15A1 collagen, type XV, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTAG2 cancer/testis antigen 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DGKD diacylglycerol kinase, delta 130kDa
DUSP1 dual specificity phosphatase 1
E2F2 E2F transcription factor 2
EDN1 endothelin 1
FGF13 fibroblast growth factor 13
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMGB2 high mobility group box 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KAT6B K(lysine) acetyltransferase 6B
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KYNU kynureninase
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNRC1 proline-rich nuclear receptor coactivator 1
PTCH1 patched 1
RANBP9 RAN binding protein 9
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP4 secreted frizzled-related protein 4
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
STK26 serine/threonine protein kinase 26
SULF1 sulfatase 1
TBC1D31 TBC1 domain family, member 31
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGIF1 TGFB-induced factor homeobox 1
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMOD1 tropomodulin 1
TMSB15A thymosin beta 15a
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
WEE1 WEE1 G2 checkpoint kinase
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APLP2 amyloid beta (A4) precursor-like protein 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
C6ORF62 chromosome 6 open reading frame 62
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHGB chromogranin B
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COX11 COX11 cytochrome c oxidase copper chaperone
CTSC cathepsin C
DCXR dicarbonyl/L-xylulose reductase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
HAT1 histone acetyltransferase 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
INSIG1 insulin induced gene 1
ITFG1 integrin alpha FG-GAP repeat containing 1
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
MALL mal, T-cell differentiation protein-like
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
NRIP3 nuclear receptor interacting protein 3
OAT ornithine aminotransferase
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLIN3 perilipin 3
RNASE6 ribonuclease, RNase A family, k6
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
TMX1 thioredoxin-related transmembrane protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
UBE2J1 ubiquitin-conjugating enzyme E2, J1
Funding