BRD-K99502566_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K99502566_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
CLDN3 claudin 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EPCAM epithelial cell adhesion molecule
EPS8 epidermal growth factor receptor pathway substrate 8
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
GPER1 G protein-coupled estrogen receptor 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIST1H2BG histone cluster 1, H2bg
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSN moesin
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
MYO10 myosin X
PDE4B phosphodiesterase 4B, cAMP-specific
PON2 paraoxonase 2
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTK2 protein tyrosine kinase 2
RAB29 RAB29, member RAS oncogene family
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNX13 sorting nexin 13
SOD2 superoxide dismutase 2, mitochondrial
TFPI2 tissue factor pathway inhibitor 2
TMEM176B transmembrane protein 176B
TRIM2 tripartite motif containing 2
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
CRISP3 cysteine-rich secretory protein 3
CTSG cathepsin G
CXCL13 chemokine (C-X-C motif) ligand 13
ELANE elastase, neutrophil expressed
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBP myelin basic protein
MFAP5 microfibrillar associated protein 5
PCOLCE2 procollagen C-endopeptidase enhancer 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLPI secretory leukocyte peptidase inhibitor
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
TMPRSS3 transmembrane protease, serine 3
TPM4 tropomyosin 4
TUSC3 tumor suppressor candidate 3
Funding