BRD-K99545815_PF-562271_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K99545815_PF-562271_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ASNS asparagine synthetase (glutamine-hydrolyzing)
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCAS3 breast carcinoma amplified sequence 3
BHLHE40 basic helix-loop-helix family, member e40
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CD47 CD47 molecule
CD48 CD48 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHRDL1 chordin-like 1
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EGR1 early growth response 1
EGR3 early growth response 3
EMX2 empty spiracles homeobox 2
EPHB2 EPH receptor B2
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
GLG1 golgi glycoprotein 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
ISYNA1 inositol-3-phosphate synthase 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITM2C integral membrane protein 2C
KLF2 Kruppel-like factor 2
LAPTM4B lysosomal protein transmembrane 4 beta
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTA4H leukotriene A4 hydrolase
LTBP3 latent transforming growth factor beta binding protein 3
MAGEA3 melanoma antigen family A3
MAGEA4 melanoma antigen family A4
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MMP9 matrix metallopeptidase 9
MSLN mesothelin
MSRB2 methionine sulfoxide reductase B2
MT1F metallothionein 1F
NBR1 neighbor of BRCA1 gene 1
NDN necdin, melanoma antigen (MAGE) family member
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMU neuromedin U
NPTX2 neuronal pentraxin II
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
NTS neurotensin
OSBPL10 oxysterol binding protein-like 10
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDIA4 protein disulfide isomerase family A, member 4
PLAC8 placenta-specific 8
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAP prosaposin
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCPEP1 serine carboxypeptidase 1
SELL selectin L
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIDT2 SID1 transmembrane family, member 2
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SRPX sushi-repeat containing protein, X-linked
SVIL supervillin
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM7SF2 transmembrane 7 superfamily member 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TRAC T cell receptor alpha constant
TRBC1 T cell receptor beta constant 1
TRIB2 tribbles pseudokinase 2
TSC22D1 TSC22 domain family, member 1
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AURKA aurora kinase A
AURKB aurora kinase B
AXIN1 axin 1
BIRC2 baculoviral IAP repeat containing 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNF cyclin F
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CGRRF1 cell growth regulator with ring finger domain 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF5 eukaryotic translation initiation factor 5
FADD Fas (TNFRSF6)-associated via death domain
FZD7 frizzled class receptor 7
H2AFX H2A histone family, member X
HOPX HOP homeobox
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KLHL9 kelch-like family member 9
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LITAF lipopolysaccharide-induced TNF factor
LYPD3 LY6/PLAUR domain containing 3
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MYBPC1 myosin binding protein C, slow type
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUP62 nucleoporin 62kDa
OXA1L oxidase (cytochrome c) assembly 1-like
PDGFA platelet-derived growth factor alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PMM2 phosphomannomutase 2
PPIF peptidylprolyl isomerase F
PQLC1 PQ loop repeat containing 1
PTX3 pentraxin 3, long
PXDC1 PX domain containing 1
RAB9A RAB9A, member RAS oncogene family
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIN2 Ras and Rab interactor 2
RPL10 ribosomal protein L10
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SHB Src homology 2 domain containing adaptor protein B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SPP1 secreted phosphoprotein 1
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TEX30 testis expressed 30
TGIF1 TGFB-induced factor homeobox 1
TSKU tsukushi, small leucine rich proteoglycan
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
XBP1 X-box binding protein 1
Funding