BRD-K99749624_linifanib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K99749624_linifanib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ADGRG6 adhesion G protein-coupled receptor G6
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
APOE apolipoprotein E
ARID5B AT rich interactive domain 5B (MRF1-like)
CALB1 calbindin 1, 28kDa
CCL2 chemokine (C-C motif) ligand 2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDN1 endothelin 1
EGF epidermal growth factor
FERMT2 fermitin family member 2
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
HACD1 3-hydroxyacyl-CoA dehydratase 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
ICAM1 intercellular adhesion molecule 1
KLF9 Kruppel-like factor 9
KRT13 keratin 13, type I
KRT7 keratin 7, type II
LAPTM5 lysosomal protein transmembrane 5
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MCAM melanoma cell adhesion molecule
MT1M metallothionein 1M
MX1 MX dynamin-like GTPase 1
MYBPC1 myosin binding protein C, slow type
NDNF neuron-derived neurotrophic factor
NEBL nebulette
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PLA2G16 phospholipase A2, group XVI
PRODH proline dehydrogenase (oxidase) 1
RASIP1 Ras interacting protein 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TACC2 transforming, acidic coiled-coil containing protein 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM47 transmembrane protein 47
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARL4C ADP-ribosylation factor-like 4C
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CLEC11A C-type lectin domain family 11, member A
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
EGR1 early growth response 1
FADS1 fatty acid desaturase 1
FGL2 fibrinogen-like 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HOXB2 homeobox B2
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
LDLR low density lipoprotein receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LYPD1 LY6/PLAUR domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MDFIC MyoD family inhibitor domain containing
METTL7A methyltransferase like 7A
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSPH phosphoserine phosphatase
RRM2 ribonucleotide reductase M2
SEPP1 selenoprotein P, plasma, 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRD T cell receptor delta locus
VCAN versican
VEGFA vascular endothelial growth factor A
Funding