BRD-M16762496_S1205_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-M16762496_S1205_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANOS1 anosmin 1
ANPEP alanyl (membrane) aminopeptidase
AQP1 aquaporin 1 (Colton blood group)
BMP2 bone morphogenetic protein 2
C3 complement component 3
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CKB creatine kinase, brain
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPA3 carboxypeptidase A3 (mast cell)
CTSZ cathepsin Z
CXCL11 chemokine (C-X-C motif) ligand 11
EGFL6 EGF-like-domain, multiple 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXPH5 exophilin 5
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFBP1 fibroblast growth factor binding protein 1
FGFR3 fibroblast growth factor receptor 3
FRZB frizzled-related protein
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLUL glutamate-ammonia ligase
GPC3 glypican 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IFITM1 interferon induced transmembrane protein 1
IL1RN interleukin 1 receptor antagonist
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
MAOA monoamine oxidase A
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MSX1 msh homeobox 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NEBL nebulette
NGRN neugrin, neurite outgrowth associated
PCSK6 proprotein convertase subtilisin/kexin type 6
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PRKCB protein kinase C, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCARB2 scavenger receptor class B, member 2
SCG2 secretogranin II
SCG5 secretogranin V
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SOX11 SRY (sex determining region Y)-box 11
SPARCL1 SPARC-like 1 (hevin)
ST14 suppression of tumorigenicity 14 (colon carcinoma)
TBXA2R thromboxane A2 receptor
TCL1A T-cell leukemia/lymphoma 1A
TUSC3 tumor suppressor candidate 3
VSNL1 visinin-like 1
WT1 Wilms tumor 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANXA5 annexin A5
ANXA6 annexin A6
APOD apolipoprotein D
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX6 armadillo repeat containing, X-linked 6
ASCC3 activating signal cointegrator 1 complex subunit 3
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
ATG3 autophagy related 3
BIN1 bridging integrator 1
BLCAP bladder cancer associated protein
CALML5 calmodulin-like 5
CDC25B cell division cycle 25B
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLTC clathrin, heavy chain (Hc)
CPNE1 copine I
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF6 eukaryotic translation initiation factor 6
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
FXR1 fragile X mental retardation, autosomal homolog 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GRWD1 glutamate-rich WD repeat containing 1
GSS glutathione synthetase
HEATR1 HEAT repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
JMJD6 jumonji domain containing 6
KLF2 Kruppel-like factor 2
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KRT7 keratin 7, type II
LASP1 LIM and SH3 protein 1
LAT2 linker for activation of T cells family, member 2
LMNA lamin A/C
MACF1 microtubule-actin crosslinking factor 1
MAGED1 melanoma antigen family D1
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MEIS3P1 Meis homeobox 3 pseudogene 1
MID1IP1 MID1 interacting protein 1
MRPS16 mitochondrial ribosomal protein S16
MYBPC1 myosin binding protein C, slow type
NOP56 NOP56 ribonucleoprotein
NQO1 NAD(P)H dehydrogenase, quinone 1
NSFL1C NSFL1 (p97) cofactor (p47)
NXN nucleoredoxin
OXTR oxytocin receptor
PANK2 pantothenate kinase 2
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PELO pelota homolog (Drosophila)
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLSCR3 phospholipid scramblase 3
POPDC3 popeye domain containing 3
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKCDBP protein kinase C, delta binding protein
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RNMT RNA (guanine-7-) methyltransferase
RPS27L ribosomal protein S27-like
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCAND1 SCAN domain containing 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SNRPE small nuclear ribonucleoprotein polypeptide E
SPATA20 spermatogenesis associated 20
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
SUCO SUN domain containing ossification factor
TARS threonyl-tRNA synthetase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFE3 transcription factor binding to IGHM enhancer 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53 tumor protein p53
TRAM2 translocation associated membrane protein 2
TRIM8 tripartite motif containing 8
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP22 ubiquitin specific peptidase 22
VCAN versican
VCP valosin containing protein
XPO1 exportin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding