BRD-M86331534_BJM-ctd2-9_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

258 genes differentially expressed following the BRD-M86331534_BJM-ctd2-9_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
ADD3 adducin 3 (gamma)
ADM adrenomedullin
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ANKRD11 ankyrin repeat domain 11
ANO1 anoctamin 1, calcium activated chloride channel
ANXA3 annexin A3
AREG amphiregulin
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CALB1 calbindin 1, 28kDa
CALML3 calmodulin-like 3
CCND2 cyclin D2
CCNG2 cyclin G2
CCNL1 cyclin L1
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP2B charged multivesicular body protein 2B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLCA4 chloride channel accessory 4
CLDND1 claudin domain containing 1
CLIC4 chloride intracellular channel 4
COL15A1 collagen, type XV, alpha 1
COL4A5 collagen, type IV, alpha 5
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTBP2 C-terminal binding protein 2
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DMTF1 cyclin D binding myb-like transcription factor 1
DSC2 desmocollin 2
DSG3 desmoglein 3
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR2 early growth response 2
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FGFR3 fibroblast growth factor receptor 3
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FZD6 frizzled class receptor 6
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPATCH8 G patch domain containing 8
GPM6B glycoprotein M6B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPR87 G protein-coupled receptor 87
GRAMD3 GRAM domain containing 3
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HOXB6 homeobox B6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IER5 immediate early response 5
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
INPP1 inositol polyphosphate-1-phosphatase
IRF6 interferon regulatory factor 6
IRF9 interferon regulatory factor 9
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0907 KIAA0907
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMP2 lysosomal-associated membrane protein 2
LARP6 La ribonucleoprotein domain family, member 6
LGALS1 lectin, galactoside-binding, soluble, 1
LITAF lipopolysaccharide-induced TNF factor
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MIR22HG MIR22 host gene
MT1E metallothionein 1E
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
NBPF10 neuroblastoma breakpoint family, member 10
NCK1 NCK adaptor protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH1 notch 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
PALLD palladin, cytoskeletal associated protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL1 pleiomorphic adenoma gene-like 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SEPT4 septin 4
SERINC1 serine incorporator 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
TANK TRAF family member-associated NFKB activator
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFA transforming growth factor, alpha
TGIF1 TGFB-induced factor homeobox 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TPD52L1 tumor protein D52-like 1
TRIB1 tribbles pseudokinase 1
TUBB2A tubulin, beta 2A class IIa
UBE2B ubiquitin-conjugating enzyme E2B
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
WBP5 WW domain binding protein 5
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
AKAP7 A kinase (PRKA) anchor protein 7
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AURKA aurora kinase A
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CIT citron rho-interacting serine/threonine kinase
DAPK1 death-associated protein kinase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FADS2 fatty acid desaturase 2
GPI glucose-6-phosphate isomerase
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPL lipoprotein lipase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKI67 marker of proliferation Ki-67
MX2 MX dynamin-like GTPase 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
PLAC8 placenta-specific 8
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
QPRT quinolinate phosphoribosyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACC3 transforming, acidic coiled-coil containing protein 3
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
Funding