BRD-U07805514_saracatinib_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-U07805514_saracatinib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BACE2 beta-site APP-cleaving enzyme 2
BAG3 BCL2-associated athanogene 3
BCAP31 B-cell receptor-associated protein 31
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
CA12 carbonic anhydrase XII
CCL19 chemokine (C-C motif) ligand 19
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COASY CoA synthase
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSL cathepsin L
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DLC1 DLC1 Rho GTPase activating protein
DUSP6 dual specificity phosphatase 6
EDN3 endothelin 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCGBP Fc fragment of IgG binding protein
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HSPH1 heat shock 105kDa/110kDa protein 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IL13RA2 interleukin 13 receptor, alpha 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JMJD6 jumonji domain containing 6
LAMC1 laminin, gamma 1 (formerly LAMB2)
LOX lysyl oxidase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LXN latexin
MAP1B microtubule-associated protein 1B
MMP7 matrix metallopeptidase 7
MSX1 msh homeobox 1
NEFL neurofilament, light polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKM pyruvate kinase, muscle
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLXNA2 plexin A2
PMP22 peripheral myelin protein 22
PNMA1 paraneoplastic Ma antigen 1
PRNP prion protein
PRR7 proline rich 7 (synaptic)
RAB5C RAB5C, member RAS oncogene family
RBM25 RNA binding motif protein 25
RCAN1 regulator of calcineurin 1
RGS4 regulator of G-protein signaling 4
S100A2 S100 calcium binding protein A2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOD2 superoxide dismutase 2, mitochondrial
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STEAP1 six transmembrane epithelial antigen of the prostate 1
TICAM1 toll-like receptor adaptor molecule 1
TM4SF1 transmembrane 4 L six family member 1
TNIP1 TNFAIP3 interacting protein 1
TOMM34 translocase of outer mitochondrial membrane 34
TXNRD1 thioredoxin reductase 1
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACOX2 acyl-CoA oxidase 2, branched chain
AHSG alpha-2-HS-glycoprotein
ALOX5 arachidonate 5-lipoxygenase
APOA2 apolipoprotein A-II
APOB apolipoprotein B
ASF1B anti-silencing function 1B histone chaperone
ASS1 argininosuccinate synthase 1
ATAD2 ATPase family, AAA domain containing 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
C5 complement component 5
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBS cystathionine-beta-synthase
CCL4 chemokine (C-C motif) ligand 4
CCNA2 cyclin A2
CCND2 cyclin D2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC3 chloride intracellular channel 3
CLU clusterin
COL1A2 collagen, type I, alpha 2
COMT catechol-O-methyltransferase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCXR dicarbonyl/L-xylulose reductase
DHCR7 7-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DMD dystrophin
EBP emopamil binding protein (sterol isomerase)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FBXO9 F-box protein 9
FXYD3 FXYD domain containing ion transport regulator 3
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAMT guanidinoacetate N-methyltransferase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GSE1 Gse1 coiled-coil protein
HACD1 3-hydroxyacyl-CoA dehydratase 1
HAL histidine ammonia-lyase
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
HPX hemopexin
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
KRCC1 lysine-rich coiled-coil 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCAM melanoma cell adhesion molecule
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MRPL57 mitochondrial ribosomal protein L57
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSRB2 methionine sulfoxide reductase B2
MYB v-myb avian myeloblastosis viral oncogene homolog
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NEB nebulin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPY1R neuropeptide Y receptor Y1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PGM1 phosphoglucomutase 1
PRDX2 peroxiredoxin 2
PROS1 protein S (alpha)
PXMP2 peroxisomal membrane protein 2, 22kDa
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SULF1 sulfatase 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TRMT5 tRNA methyltransferase 5
TST thiosulfate sulfurtransferase (rhodanese)
TTN titin
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WBP5 WW domain binding protein 5
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZWINT ZW10 interacting kinetochore protein
Funding