BRD-U22633929_XMD11-85H_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-U22633929_XMD11-85H_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AHSG alpha-2-HS-glycoprotein
APOA2 apolipoprotein A-II
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BICC1 BicC family RNA binding protein 1
C5 complement component 5
C7 complement component 7
CCL8 chemokine (C-C motif) ligand 8
CD36 CD36 molecule (thrombospondin receptor)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSPG4 chondroitin sulfate proteoglycan 4
CTSB cathepsin B
DFNA5 deafness, autosomal dominant 5
DIRAS3 DIRAS family, GTP-binding RAS-like 3
E2F2 E2F transcription factor 2
EGR2 early growth response 2
EMP1 epithelial membrane protein 1
EPHA4 EPH receptor A4
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GPC3 glypican 3
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HLF hepatic leukemia factor
HMOX1 heme oxygenase 1
IGFBP1 insulin-like growth factor binding protein 1
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6ST interleukin 6 signal transducer
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF2C kinesin family member 2C
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
LPL lipoprotein lipase
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRN3 leucine rich repeat neuronal 3
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MPP1 membrane protein, palmitoylated 1, 55kDa
MXRA5 matrix-remodelling associated 5
OXTR oxytocin receptor
PAX8 paired box 8
PDE4DIP phosphodiesterase 4D interacting protein
PHACTR1 phosphatase and actin regulator 1
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
PLTP phospholipid transfer protein
PROS1 protein S (alpha)
PTN pleiotrophin
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
SELL selectin L
SOX9 SRY (sex determining region Y)-box 9
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STXBP6 syntaxin binding protein 6 (amisyn)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TERT telomerase reverse transcriptase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP4 TIMP metallopeptidase inhibitor 4
TNC tenascin C
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TSPYL5 TSPY-like 5
UPK1B uroplakin 1B
VASH2 vasohibin 2
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA2 annexin A2
ATF5 activating transcription factor 5
ATP11B ATPase, class VI, type 11B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAPN2 calpain 2, (m/II) large subunit
CD24 CD24 molecule
CFAP20 cilia and flagella associated protein 20
CKLF chemokine-like factor
COX5B cytochrome c oxidase subunit Vb
FRZB frizzled-related protein
FXYD3 FXYD domain containing ion transport regulator 3
HAT1 histone acetyltransferase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IRS2 insulin receptor substrate 2
KIF14 kinesin family member 14
MMP11 matrix metallopeptidase 11
NMRK1 nicotinamide riboside kinase 1
NPTX2 neuronal pentraxin II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARP2 poly (ADP-ribose) polymerase 2
PDGFC platelet derived growth factor C
PDHX pyruvate dehydrogenase complex, component X
PLN phospholamban
PTEN phosphatase and tensin homolog
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFC2 replication factor C (activator 1) 2, 40kDa
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SFRP4 secreted frizzled-related protein 4
SLC35F2 solute carrier family 35, member F2
THAP11 THAP domain containing 11
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNIP1 TNFAIP3 interacting protein 1
TOR1A torsin family 1, member A (torsin A)
TRIM14 tripartite motif containing 14
TXNDC9 thioredoxin domain containing 9
Funding